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梧桐清声 2013-07-28 22:44 1 票支持; 0 票反对
课程是系统生物学的入门课程。虽然是入门课程,但是这门课因为是一门交叉学科,因此需要对生物和数理两方面有一定了解。生物方面,需要本科高年级水平生物学基础,比如酶学反应,动作电位。数理基础方面,至少要知道一些名称例如常微分方程偏微分方程,但是不需要解方程。
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开始时间: 04/22/2022 持续时间: 10 weeks
所在平台: CourseraArchive 课程类别: 生物与生命科学 大学或机构: Icahn School of Medicine at Mount Sinai(西奈山伊坎医学院) 授课老师: Ravi Iyengar |
课程主页: https://www.coursera.org/course/sysbio
课程评论: 1 个评论
This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems?
The course will develop multiple lines of
reasoning to answer the questions listed above. Two major reasoning threads
are: the design, execution and interpretation of multivariable experiments that
produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate
“how” cell- level functions arise and “why” mechanistic knowledge allows us to
predict cellular behaviors leading to disease states and drug responses.
Topics covered include:
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梧桐清声 2013-07-28 22:44 1 票支持; 0 票反对
课程是系统生物学的入门课程。虽然是入门课程,但是这门课因为是一门交叉学科,因此需要对生物和数理两方面有一定了解。生物方面,需要本科高年级水平生物学基础,比如酶学反应,动作电位。数理基础方面,至少要知道一些名称例如常微分方程偏微分方程,但是不需要解方程。
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An introduction to current concepts of how cellular molecules come together to form systems, how these systems exhibit emergent properties, and how these properties are used to make cellular decisions.
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