Introduction to Systems Biology

开始时间: 04/22/2022 持续时间: 10 weeks

所在平台: CourseraArchive

课程类别: 生物与生命科学

大学或机构: Icahn School of Medicine at Mount Sinai(西奈山伊坎医学院)

授课老师: Ravi Iyengar

课程主页: https://www.coursera.org/course/sysbio

课程评论: 1 个评论

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课程详情

This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions.  Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems.  These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems?   What are the mechanisms by which emergent behaviors of systems arise?  What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems?

The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations.  Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.

课程大纲

Topics covered include:

  • Systems Level Reasoning: Bottom-Up and Top-Down Approaches for Complex Systems
  • Cell Signaling Pathways: Molecules to Pathways, cAMP and MAP-kinase Pathways
  • Signal Flow: Pathways to Networks
  • The Actin Cytoskeleton: The Cell Motility Machine
  • Mathematical Representations of Cell Biological Systems Time and Space
  • Gathering Large Data Sets in Genomics and Proteomics
  • Inferring Modules: Computational Analysis of Large Data Sets; Building Networks
  • Small Scale Systems Biology Experiments
  • Identifying Emergent Properties by Computation:  Dynamical Models
  • Emergent Properties: Ultrasensitivity, Bistability, Robustness & Fragility
  • Modules to Functions: Control Systems
  • Module-Boundaries: Sharp and Fuzzy, Interactions between Subcellular Modules
  • Emergence of Cellular Functions from Subcellular Modules
  • Systems Analysis of Complex Diseases
  • Systems Pharmacology: Understanding Drug Action from a Systems Perspective

课程评论(1条)

1

梧桐清声 2013-07-28 22:44 1 票支持; 0 票反对

课程是系统生物学的入门课程。虽然是入门课程,但是这门课因为是一门交叉学科,因此需要对生物和数理两方面有一定了解。生物方面,需要本科高年级水平生物学基础,比如酶学反应,动作电位。数理基础方面,至少要知道一些名称例如常微分方程偏微分方程,但是不需要解方程。
老师是大牛,对本领域十分熟悉,选择的内容很有代表性,上课内容几乎没有课本内容,全部为系统生物学领域内经典或者有代表性的论文串讲,因此紧跟领域的发展。所有论文全部列出来了,很方便查阅,也方便有兴趣的继续阅读论文原文加深理解。但是不做课外阅读仍然可以听懂全部课程。
讲课方式比较枯燥,坚持下来需要对这个领域有相当的兴趣。难度方面,如果有基础的话不是太难,如果没有基础的话挺难的。

课程简介

An introduction to current concepts of how cellular molecules come together to form systems, how these systems exhibit emergent properties, and how these properties are used to make cellular decisions.

课程标签

生物 生物学 生物学导论 系统生物学 生物系统 系统生物学导论 西奈山医学院

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