|
所在平台: Udemy |
课程主页: https://www.udemy.com/course/structural-bioinformatics/
课程评论：没有评论
**课程名称：** 结构生物信息学 **课程概述：** 本课程深入探讨结构生物信息学及其在计算药物发现中的应用。您将了解蛋白质作为药物靶点的重要性，分析其结构的关键性，以及这如何有助于发现治疗疾病的药物。课程面向希望深入理解生物大分子结构与功能之间复杂关系的**学生和专业人士**。 结构生物信息学在揭示生物分子系统的复杂性方面发挥着关键作用，连接了实验数据与计算分析。您将学习研究和建模蛋白质三维结构的**原理和技术**，包括： * 分子可视化 * 结构数据库 * 同源建模 * 分子对接与虚拟筛选 * 分子动力学模拟 * 蛋白质-配体相互作用 **学习收益：** * 获得结构生物信息学分析的**前沿计算工具和软件**的实践经验。 * 理解支配蛋白质-配体结合的**原理**，并探索预测和分析这些相互作用的方法。 * 掌握如何**导航主要的结构数据库**以检索和分析实验确定的结构。 * 通过**分子动力学模拟**揭示生物分子的**动态性质**。 * 理解**构象变化**的原理及其在理解生物机制中的意义。 * 通过**药物发现和开发的案例研究**，掌握结构生物信息学如何加速药物靶点的识别和新型疗法的设计。 本课程将带您开启结构生物信息学之旅，掌握揭示生命分子结构奥秘的技能。
This course is about structural bioinformatics and its application in computational drug discovery. You will gain knowledge about importance of protein as drug target, the importance of analyzing its structure, and how this can help in discovering a drug that might fight a certain disease. The course is designed for students and professionals seeking an in-depth understanding of the intricate relationship between structure and function in biological macromolecules.Structural bioinformatics plays a pivotal role in unraveling the complexities of biomolecular systems, bridging the gap between experimental data and computational analysis. Throughout this course, participants will delve into the principles and techniques used to study and model the three-dimensional structures of proteins. Topics covered include molecular visualization, structural databases, homology modeling, molecular docking and virtual screening, molecular dynamics simulations, and protein-ligand interactions.Gain hands-on experience with state-of-the-art computational tools and software used in structural bioinformatics analysis.Understand the principles governing protein-ligand binding and explore methods for predicting and analyzing these interactions.Navigate through major structural databases to retrieve and analyze experimentally determined structures.Uncover the dynamic nature of biomolecules through molecular dynamics simulations. Grasp the principles of conformational changes and their implications in understanding biological mechanisms.Embark on a transformative journey into the world of structural bioinformatics and gain the skills to unravel the secrets hidden within the molecular architecture of life. Explore real-world applications by dissecting case studies in drug discovery and development. Understand how structural bioinformatics accelerates the identification of drug targets and the design of novel therapeutics.
