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课程主页: https://www.udemy.com/course/pharmperfect61/
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**课程名称：** pharmperfect61 **课程概述：** 本课程旨在深入讲解临床中最常用的实验室检查及其临床意义，涵盖以下关键领域： 1. **体液实验室检测：** * 腹水（ascites） * 胸腔积液（胸水、血胸、乳糜胸） * 脑脊液（细菌性或出血性） * 羊水 * 关节腔积液（针对类风湿性关节炎） 2. **糖尿病并发症与预后相关的实验室检查：** * 鉴别诊断糖尿病酮症酸中毒（DKA）与高渗性高血糖状态（HHS） 3. **肝功能检查：** * ALT, AST, ALP, GGT 的结果解读 * 区分肝细胞损伤、肝后（阻塞性黄疸）或肝前性病因 4. **胰腺功能检查：** * 淀粉酶（Amylase）与脂肪酶（Lipases）的意义 * 鉴别急性与慢性胰腺炎 * 慢性胰腺炎特异性检测（粪便弹性蛋白酶） 5. **肾功能检查：** * 肾小球滤过率（GFR）原理 * 常用检测（尿素、肌酐、胱抑素-C）及其效率比较 6. **自身免疫性疾病：** * 自身免疫性疾病的一般原理 * 常见自身免疫性疾病的遗传与环境因素 * 重点疾病：乳糜泻（Celiac disease）、类风湿性关节炎（Rheumatoid arthritis）、系统性红斑狼疮（Systemic Lupus Erythematosus） 7. **出血性疾病：** * 正常凝血生理机制 * 异常情况（遗传性或病理性凝血因子缺乏） * 出血倾向监测的关键检测：PT, aPTT, INR 8. **激素：** * 各类激素类型 * 酪氨酸激酶受体与细胞内受体（如糖皮质激素）的一般原理 * 激素相互作用示例 9. **肿瘤标志物：** * 癌症发生机制、癌基因与 P53 突变的一般原理 * 常见的组织特异性或肿瘤特异性肿瘤标志物 10. **临床案例复习与解读：** * 结合先前内容对临床病例进行分析和解读 11. **血液学与电解质紊乱：** * **红细胞部分：** 贫血与红细胞增多症的常见原因、贫血鉴别诊断报告解读 * **白细胞部分：** 白血病及其类型（根据报告解读和年龄分为 ALL & AML） * **电解质紊乱部分：** 酸中毒与碱中毒的判断（呼吸性或代谢性原因）及相应的管理方法
In this course we will include the clinical significance for most commonly known lab tests including:1. Biological Fluids lab tests: ascites, pleural effusion (Hydrothorax, Hemothorax & Chylothorax), CSF (Bacterial or Hemorrhagic), Amniotic fluid & Intra-articular fluid for rheumatoid arthritis.2. Diabetic complications & lab tests for good prognosis: this includes how to perform differential diagnosis between DKA & HHS (Hyperglycemic Hyperosmolar state)3. Liver Function tests: ALT, AST, ALP & GGT - How to interpret results and to reach a conclusive diagnosis whether the condition is a hepatocellular injury, Post-hepatic (Obstructive jaundice) or Pre-hepatic.4. Pancreatic function tests: Amylase & Lipases, their significance in pancreatic function tests & to determine whether the condition is acute or chronic pancreatitis - Chronic pancreatitis specific lab tests (fecal elastase).5. Renal Function tests: starting from the GFR principle ending with most commonly used tests Urea, Creatinine & Cystatin-C (The most efficient one).6. Autoimmune Diseases: General autoimmune diseases principle, common autoimmune diseases including the genetic & environmental factor for each one. Such included diseases in this chapter: Celiac disease, Rheumatoid arthritis & Systemic Lupus Erythrematousus.7. Bleeding Disorders: normal coagulation physiological mechanism & abnormal conditions like hereditary or pathologic clotting factors deficiency. Essential tests for bleeding tendency monitoring; PT, aPTT & INR.8. Hormones: this topic includes various hormones types & the general principle for tyrosine kinase surface receptors & intracellular receptors (corticosteroids) - Some Hormonal interaction examples.9. Tumor Markers: the general principle for cancer pathogenesis, oncogenes & P53 mutations. Common tumor markers which may be tissue specific or cancer (tumor specific)10. Revision Clinical Cases with their interpretation regarding previously illustrated topics.11. Hematology Chapter & Electrolyte Imbalance: This chapter will include the following points:-RBCs Section: anemia & polycythemia common causes, report interpretation for anemia differential diagnosisWBCs Section: Leukemia & various types based on report interpretation and age (ALL & AML)Electrolyte Imbalance Section: Acidosis & Alkalosis, how to determine whether the cause is respiratory or metabolic & the consequetive management approach.
