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所在平台: Udemy |
课程主页: https://www.udemy.com/course/pharmaceutical-novel-drug-delivery-system-course-2023/
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课程名称：药物新型给药系统课程-2025 课程概述： 随着对药物药代动力学和药效学行为理解的深入，药物给药系统的开发正在朝着更合理化的方向发展。药物只有在特定的速率和浓度下、送达目标部位才会发挥治疗效果。然而，许多有效药物因难以送到目的地而失去效用。因此，各种剂型的开发旨在促进药物的施用和改善给药效果。传统的给药系统在现代药物应用中显得有些滞后，因为我们正在不断开发新型药物，而现有的给药系统无法充分发挥这些药物的潜力。这就引出了新型药物给药系统的需求。 新型药物给药系统的必要性： 传统给药系统在以下方面存在不足： - 药物吸收受各种理化障碍的影响。 - 药物非特异性分布，导致对非靶细胞的副作用。 - 药物易受代谢和排泄器官的攻击，造成损失。 - 因此，药物在靶点的浓度无法达到要求。 新型给药系统可消除上述缺陷，降低复杂的给药调度，减少误服的可能性，并有效递送生物药物（如肽、蛋白质、反义寡核苷酸等），这些生物制剂因分子大、水溶性和不稳定性而难以通过传统系统送达。 新型药物给药系统的治疗益处： - 提高用药的便利性 - 改善疗效 - 减少副作用 - 避免高昂的医疗费用 - 调整药物的作用持续时间 - 减少给药频率 - 精确控制药物释放位置 - 维持恒定药物浓度 - 减少急诊就诊次数 经济效益： - 简化给药方案 - 整体减少医疗成本 课程目标： - 介绍基本术语与定义、优势与劣势、药物候选选择标准。 - 根据扩散、溶解和离子交换原理设计控制释放配方。 - 掌握相关药物的物理化学和生物特性。 课程范围： 本课程旨在传授新型药物给药系统的基本知识。 课程内容： - 课程概述 - 新型药物给药系统的优势 - 影响新型药物给药系统的因素 - 新型药物给药系统的分类与种类 - 控制给药系统 - 扩散与溶解 - 离子交换树脂 - 胃内保持与经皮给药系统 适合对象： 药学学生、生命科学毕业生、医生、研究者、投资者等。 课程收益： 完成课程后，学生将能够： - 理解新型药物给药系统的发展方法。 - 理解药物和聚合物选择标准、配方与评估。 - 了解定制、缓释和控制释放剂型的需求、概念、设计与评估。 - 制备和评估各种新型药物给药系统。 - 获得终身课程访问权限和学习材料。 - 颁发结业证书。
Now day's Recent advances in the understanding of pharmacokinetic & pharmacodynamic behaviour of drug have offer a more rational approach to the development of optimal drug delivery system.Drug can show its therapeutic effect only if it is delivered at a target site at a particular rate and concentration. Most effective drugs are rendered useless due to the difficulties in delivering them to their target. That is why various types of dosage forms serve many purposes including facilitating drug administration and improving drug delivery. However, traditional or conventional drug delivery systems seem to lag a bit when it comes to modern medication.We are developing new kinds of drugs and discoveries are still going on! We need new delivery systems to give justice to those drugs. This is where novel drug delivery comes into the picture. We need novel drug delivery systems in many aspects of medication.Need for Novel drug delivery systemThe traditional drug delivery system fails to provide the following:The proper drug absorption does not heppen because of various physiochemical barriers.The drug gets non-specifically distributed which contributes to its side effects by affecting non-target cells.The drug many times becomes vulnerable to metabolizing and excretary organs leading to losses.Due to all these reasons, the drug does not match the required concentration in the target.Novel drug delivery can eliminate these flaws.Traditional dosage forms have complex dosing schedules. As a result, many people mistakenly take the wrong medication and get into some other trouble.With the advancements in biotechnology and molecular biology, we have various biopharmaceuticals available such as peptides, proteins, antisense oligonucleotides, siRNA, etc. But these compounds are very difficult to deliver by traditional delivery systems due to their large molecular size, water solubility, and instability.Therapeutic benefits of Novel drug delivery system:Make medication more user-friendlyImproved resultsReduced side effectsAvoidance of costly healthcare servicesTweaking the duration of action of drugsDecrease in dosing frequencyWe can decide where the drug would be releasedConstant drug levels maintenanceReducing the number of emergency visitsEconomic benefits of Novel drug delivery system:Simple administration of regimenOverall reduction in the healthcare costObjectives:Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles.Physicochemical and biological properties of drugs relevant to controlled release formulationsScope: This Course is designed to impart basic knowledge on the area of novel drug delivery systems.Contents of course:Course overview IntroductionAdvantages of NDDSFactors affecting NDDSTypes of NDDS/Classification of NDDSControlled Drug Delivery systemDiffusion DissolutionIon Exchange resinGastro retentiveTransdermal Delivery systemEligibility: Pharmacy Students, Any lifescience graduates, Doctors, Physicians, Researchers, Investors etc..Benefits of course: Upon completion of the course student shall be able To understand various approaches for development of novel drug delivery systems.To understand the criteria for selection of drugs and polymers for the development of Novel drug delivery systems, their formulation and evaluation The need, concept, design and evaluation of various customized, sustained and controlled release dosage forms.To formulate and evaluate various novel drug delivery systemsLifetime course access and study materialCertificate of completion
