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所在平台: Udemy |
课程主页: https://www.udemy.com/course/pain-neuroscience-and-the-chemistry-of-pain/
课程评论：没有评论
**课程名称：** 疼痛神经生物学、神经炎症与慢性疼痛 **课程概述：** 本课程是一门关于疼痛科学的高阶课程，深入探讨慢性疼痛的神经生物学机制，以及饮食和生活方式如何导致身体化学环境向促炎性主导转变，进而驱动慢性疼痛等炎性疾病。课程将详细介绍“神经-免疫系统”的概念、免疫细胞及其介质，探讨细胞因子、脂质介质和生长因子对神经性疼痛的影响，以及“内源性溶解系统”失调时会发生什么。此外，课程还将讲解特异性促溶解介质如何解决神经炎症，神经炎症穿越血脑屏障后会产生何种影响，腰椎盘退变的有症状与无症状的区别，以及如何调整身体化学环境以趋向促溶解状态等等。 本课程共分为 5 个模块，总时长超过 6 小时。 **模块一：** 关注伤害性感受（nociception）的基本神经解剖学以及导致中枢致敏的神经生理学变化。我们将回顾感觉系统的基础知识，讨论下行抑制通路，以及外周和中枢致敏。 **模块二：** 深入探讨神经-免疫系统，重点讲解慢性疼痛的神经免疫学，包括驱动持续性伤害性感受或促进缓解的免疫细胞和介质。我们将讨论平衡和调节的免疫系统在解决炎症问题中的重要性，以及“内源性溶解系统”如何通过免疫细胞极化来促进调节性免疫系统向促溶解状态转变。 **模块三：** 剖析腰椎盘源性疼痛，重点阐述身体的化学环境如何决定腰椎盘退变的有症状与无症状、症状的严重程度，以及为何有些患者完全康复，而另一些患者则发展为慢性疼痛。 **模块四：** 追溯我们身体化学组成的进化起源，并探讨现代生活方式与驱动我们稳态机制的身体化学环境之间的冲突。这会导致许多“失配性疾病”，如骨关节炎、心脏病、糖尿病和慢性疼痛。 **模块五：** 总结和回顾课程中学习到的所有内容。
This is a high level course on Pain Science, teaching the neuroscience of chronic pain and how diet and lifestyle pushes our chemistry towards a pro-inflammatory dominance that drives chronic inflammatory diseases such as chronic pain. What is the "Neuro-immune system"?What are the Immune cells and thier mediators?What is the effect of various cytokines, lipid mediators, and growth factors on nociplastic pain?What happens when the "endogenous resolution system" fails?How do specialized pro-resolving mediators work to resolve neuroinflammation?What are the effects of neuroinflammation when it crosses the Blood Brain Barrier?What is the difference between symptomatic vs. asymptomatic disc degeneration?How can we shift our chemistry towards pro-resolution?And SO MUCH MORE.....This course is divided into 5 Modules and over 6 hours of content. Module 1: Covers basic neuroanatomy of nociception along with the neurophysiological changes that lead to central sensitization. We recap the basics of the sensory system, discuss the descending inhibitory pathways, and discuss peripheral and central sensitization. Module 2: Dives in to the meat of the course as we cover the neuro-immune system. Here we will teach students about the neuroimmunology of chronic pain, including the immune cells and mediators that either drive ongoing nociception or lead to resolution. We discuss the importance of a balanced and regulated immune system in order to resolve inflammatory issues. You will learn about the "endogenous resolution system" and how immune cell polarization shifts the balance towards pro-resolution in a regulated immune system. Module 3: This module breaks down lumbar discogenic pain and how chemistry determines symptomatic vs. asymptomatic disc degeneration, symptom severity, and why some patients resolve completely while others develop chronic pain. Module 4: Finally, we dive in to the evolutionary origin of our chemistry and how our modern lifestyles are in conflict with the chemistry that drives our homeostatic mechanisms. This leads to many "mismatch diseases" like osteoarthritis, heart disease, diabetes, and chronic pain. Module 5: The final module will recap and summarize all that we've learned in the course.
