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所在平台: Udemy |
课程主页: https://www.udemy.com/course/nomenclature-of-stereo-isomers/
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**课程名称:** 立体异构体的命名 [R-S & E-Z] **课程概述:** 本课程主要介绍在立体化学中，具有相同分子式和原子连接顺序（化学结构）但三维空间原子排列方式不同的分子——立体异构体。与结构异构体（原子连接方式不同）不同，立体异构体在化学结构式上是相同的，因此传统的IUPAC命名法无法区分它们。课程将引入“立体异构体命名法”来解决这一问题。 **课程内容:** 1. **Cahn-Ingold-Prelog (CIP) 优先规则:** * 这是区分E-Z和R-S命名法的共同基础。 * 通过原子序数来区分连接到立体中心的基团的优先级。 * CIP优先规则有助于精确命名所有有机分子的每一个立体异构体。 2. **烯烃的E-Z命名法:** * 专门用于双键立体中心。 * 当顺反异构体命名法失效时，E-Z命名法的重要性尤为突出。 * 涵盖几何异构体的相关情况。 3. **'sp3' 杂化碳的R-S命名法:** * 适用于四面体立体中心。 * 涵盖对映异构体（光学异构体）的相关情况。
In stereochemistry, stereoisomerism, or spatial isomerism, is a form of isomerism in which molecules have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space. This contrasts with structural isomers, which share the same molecular formula, but the bond connections or their order differs. By definition, molecules that are stereoisomers of each other represent the same structural isomer. Since their structural formulae are same, simple IUPAC nomenclature rules give same name to both the stereo-isomers. To differentiate them further few rules have been introduced under the name "Nomenclature of Stereo-isomers". Course includes 1. Cahn-Ingold-Prelog (CIP) priority rules; This is the common step towards both E-Z and R-S Nomenclature. Here we differentiate the groups attached to the stereocenter based on atomic number. The CIP sequence rules contribute to the precise naming of every stereoisomer of every organic molecule 2. E-Z nomenclature of alkenes; This nomenclature is specifically applicable to the double-bonded stereocenters. The need of E-Z nomenclature becomes significant where cis trans nomenclature fails. Here we have the cases of geometrical isomerism.3. R-S nomenclature of 'sp3' hybridized carbon; This nomenclature is applicable for tetrahedral stereocenters. Here we have the cases of enantiomers (optical isomers).
