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所在平台: Udemy |
课程主页: https://www.udemy.com/course/molecular-biology/
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**分子生物学课程概览** 本课程将深入介绍分子生物学这一迷人领域的核心概念。我们将从DNA复制开始，探究其半保守复制机制、互补碱基配对以及DNA复制过程中涉及的关键酶，如DNA拓扑异构酶和DNA聚合酶。我们还将学习DNA损伤和多种修复机制，包括核苷酸切除修复、碱基切除修复和错配修复。 接着，课程将重点关注转录过程，即DNA信息如何转化为RNA。我们将详细解析原核生物和真核生物转录的机制，包括启动、延伸和终止。此外，我们还将探讨转录后修饰，如加帽、加尾和剪接，以及影响转录的抑制剂。 第三单元将聚焦翻译，即RNA信息如何指导蛋白质的合成。我们将深入了解遗传密码的特点、密码子-反密码子配对以及“摆动假说”。课程还将详细讲解原核生物和真核生物的翻译过程，包括起始、延伸和终止，并讨论翻译过程中的能量消耗。最后，我们将学习翻译后修饰，以及如何影响蛋白质的功能。 第四单元将探讨基因表达的调控。我们将学习增强子和沉默子的作用，以及基因组织和组蛋白共价修饰如何影响基因表达。课程还将重点介绍原核生物中具有代表性的基因调控系统，如乳糖操纵子和色氨酸操纵子，并探讨真核生物中类似的调控机制。 **课程适合人群：** 本课程适合对生命科学、生物技术、医学等领域感兴趣的本科生、研究生以及任何希望深入了解分子生物学基本原理的学习者。 **学习收益：** 通过本课程的学习，您将能够： * 理解DNA复制、转录和翻译的核心机制。 * 掌握DNA损伤与修复的关键过程。 * 了解蛋白质合成的分子基础及其调控。 * 能够分析和解释基因表达调控的策略。 * 为进一步深入学习分子生物学相关领域打下坚实基础。
Introduction to the course Provides information onBrief introduction on TutorBenefits from the courseTopics/Structure of the courseWho can enroll to the course UNIT 1: Replication Central Dogma of biologyReplication of DNASemiconservative replication Complimentary base pairingSupercoil and DNA topoisomeraseReplication forkDNA synthesis catalysed by DNA Polymerase DNA Damage and Repair Nucleotide Excision Repair Base Excision Repair Mismatch Repair system UNIT 2: Transcription Central Dogma of Life what is Transcription Mechanism Of Transcription In Prokaryotes Initiation elongation Termination In Eukaryotes Initiation is initiated with help of promotor regionTAAT Box and Pribnow BoxElongation Enhancers and Silencers Termination Post Transcriptional Modification Addition of Cap and Poly A tail Splicing Of mRNA mRNA Editing Inhibitors of Transcription Reverse Transcriptase and RNA Degradation.UNIT 3: Translation Genetic Code Features Of Genetic Code Codon - Anticodon Pairing wobble HypothesisLink Between Amino Acid And Nucleic Acid Translation In Prokaryotes Initiation Elongation Termination How much Energy is consumed during the Process Translation in Eukaryotes Initiation with Pre Initiation complex Association of Ribosomal Subunit Elongation Termination using Termination Codons Release Factors Post Translational Modification Trimming Structural Reorganisation Modification at N and C Terminal Ends Covalent Modification How much Of energy is consumed during the process of Translation Unit 4: Regulation of Gene Expression Enhancers and silencers House keeping and invisible genes One cistron -one subunit concept DNA organisation and Gene expression Covalent Modification of Histones control Gene expression Regulation of Gene Expression in Prokaryotes: Lac operon structure of Lac Operon Tryptophan regulation in Eukaryotes Structure of Tryptophan Operon with structural gene
