Medical Biochemistry: Metabolism of Fats and Lipids

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**课程名称:** 医学生物化学:脂肪与脂质代谢 **课程概述:** 本课程将带您深入探索脂肪和脂质在人体内的完整代谢过程。我们将从食物中的脂肪在肠道中的消化吸收开始,追溯它们如何被身体细胞利用。您将了解在摄入高碳水化合物餐后,身体如何合成脂肪并将其包装成脂蛋白。此外,课程还将详细讲解在禁食状态下脂肪和脂质代谢的变化。 **课程结构:** 本课程共分为五个部分,包含约十八个教学视频,内容详实且生动有趣: **第一部分:摄入富含脂肪的食物** * 脂肪与脂质消化概述 * 消化脂肪作为乳糜微粒的吸收与脂肪泻 **第二部分:摄入高碳水化合物餐** * 脂肪酸生物合成 * 甘油三酯合成 * 胆固醇合成 * 脂蛋白代谢 * 低密度脂蛋白受体 * 高脂血症 **第三部分:禁食状态** * 脂质动员 * 脂肪酸氧化概述 * 过氧化物酶体对超长链脂肪酸的氧化 * 脂肪酸转运至线粒体 * 脂肪酸的β-氧化 * 奇数碳链脂肪酸的氧化 * 酮体代谢 **第四部分:磷脂、鞘磷脂与类花生酸** * 磷脂 * 鞘磷脂与鞘脂质病 * 类花生酸 **第五部分:临床病例题目回顾** * 与脂肪与脂质代谢相关的临床选择题回顾。 本课程旨在以引人入胜的方式,全面讲解脂肪与脂质的代谢机制,并结合临床案例,帮助学习者建立扎实的生物化学知识体系。

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In this course, we will start our journey with the story of fat digestion and absorption in the intestines, all the way to how our body cells utilize the absorbed chylomicron units. We will tell the story of how fat is synthesized and packaged as lipoproteins after eating a high carbohydrate meal. Then we will look at what happens to fats & lipids metabolism when we are in a fasting stateTo teach this in a very interesting manner, we have divided this course into four (5) sections with about eighteen (18) lecture videos arranged in four (4) sections with the fifth section set aside to review clinical case questions.The content of this course is as follow:Eating Food Rich in Fats & Lipids:Overview of Fats & Lipids DigestionAbsorption of Digested Fats as Chylomicrons and SteatorrheaEating High Carbohydrate Meals:Fatty Acids BiosynthesisTriglyceride SynthesisCholesterol SynthesisLipoproteins MetabolismLDL ReceptorsHyperlipidaemiasFasting StateLipid MobilizationOverview of Fatty Acids OxidationPeroxisomal Oxidation of VLCFAFatty Acids Transport into the MitochondriaBeta Oxidation of Fatty AcidsOxidation of Odd Chains Fatty AcidsKetone Bodies MetabolismPhospholipids, Sphingolipids & EicosanoidsPhospholipidsSphingolipids & SphingolipidosesEicosanoidsWe will also consider some clinical Multiple Choice Questions Review as it relates to Fats & Lipids Metabolism.

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