Hepatitis C, diagnosis and treatment in various situations

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课程主页: https://www.udemy.com/course/hepatitis-c-diagnosis-and-treatment-in-various-situations/

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课程名称:丙型肝炎:不同情况下的诊断与治疗 本课程概述了丙型肝炎(HCV)感染,包括其传播途径、慢性化几率,以及在无并发症感染下的症状。课程还详细阐述了并发症及其症状,特别是简要的临床表现。 诊断部分将深入探讨所需的检查,包括用于诊断感染的血液检测以及规划治疗所需的测试。并发症可以通过临床表现诊断,但部分病例可能需要进一步检查,如血液测试、腹部超声、CAT扫描或内镜检查。 治疗方面,课程介绍了现有治疗方案,重点介绍了四类直接抗病毒药物(DAA),均为口服药物:NS3/4A蛋白酶抑制剂、NS5A抑制剂和NS5B聚合酶抑制剂。NS5B药物又可分为核苷类或非核苷类,其中dasabuvir目前在通用治疗方案中已不再使用。 课程将讨论非肝硬化初治患者的治疗,通常采用两种药物联合治疗八至十二周。其他并发临床情况的治疗将在课程的后续部分进行探讨。

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This portion of the course describes the hepatitis C infection? How this infection is transmitted and what are the chances of this becoming chronic. What are its symptoms in uncomplicated infection? What are the complications and what are the symptoms in those complications especially the clinical presentation in brief. The diagnostic outline is discussed in detail. What investigations are required for the diagnosis of infection and what are the tests required to plan treatment? The complications can be diagnosed clinically. Some cases may require investigations like blood tests, ultrasound, and CAT scanning of the abdomen or endoscopy to pick up the complications. The outline of treatment available is given. Mention is made of different classes of directly acting antiviral (all oral) available for treatment. These four classes include 3/4 A protease inhibitors, NS5A polymerase inhibitors, and NS5B polymerase inhibitors. The NS5B drugs may be divided into nucleotide or non-nucleotide classes. Of these later dasabuvir is currently not used in general treatment algorithms. The treatment of non-cirrhotic treatment-naive patients is discussed. This treatment uses a combination of two drugs used for a period of eight to twelve weeks. The treatment of complicated clinical situations is also discussed in other sections of the course.

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