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所在平台: Udemy |
课程主页: https://www.udemy.com/course/genome-stability-in-precision-medicine-course/
课程评论：没有评论
课程名称：精准医学中的基因组稳定性课程 概述：本课程专为从事遗传学和基因组研究的医生和生物医学科学家设计。尽管我们尚无法像阅读书籍一样完整理解整个基因组的所有核苷酸，但生物学家们仍然认为我们的基因组是稳定的，然而证据表明，基因组实际上在不断经历断裂和修复。每个细胞每分钟大约会发生10,000次DNA断裂。DNA的断裂和修复之间的平衡至关重要，一旦失衡将导致神经疾病和癌症等疾病的出现。为了以更精确的方式设计新的治疗方案，能够全面阅读和理解整个基因组的组成及细胞如何确保这一序列在细胞或生物体的整个生命过程中保持不变显得至关重要。本课程将探讨基因组如何保持稳定、理解基因组不稳定性及其对人类健康影响的技术。最终目标是深入理解精准医学的原则，以改善健康结果。 学习成果： - 获取内源性和外源性基因组不稳定性的基本信息 - 学习各种类型的基因组不稳定性和修复DNA断裂的机制 - 将理解应用于不同的场景，包括临床案例研究 - 深刻理解用于捕捉证据的实验方法 - 利用这些知识制定更有效和精准的治疗方案
This course is designed for physicians and biomedical scientists engaged in genetics and genomics. We still cannot read and fully understand the nucleotides of an entire genome as you would read a book from beginning to end. Biologists still think our genome is stable, yet the evidence shows that it suffers from breaking and sealing all the time. There are approximately 10,000 DNA breaks per cell per minutes. Breaking and sealing the DNA is a fine balance, which if lost leads to diseases such as neurological disorders and cancer. To design new therapeutics in a more precise manner, it is critical to be able to read and understand the composition of the entire genome and how cells ensure that this sequence remain the same during the lifetime of a cell or an organism. In this course, we will see how our genome is kept stable, techniques to read and understand its instability and the consequences they might have on human health. The ultimate outcome is to enable a thorough understanding of the principles of precision medicine to improve health outcomes.Learning Outcomes:· Obtain fundamental information of endogenous and exogenous sources of genomic instability· Learn the various types of genomic instability and mechanisms of fixing DNA breaks· Critically apply their understanding to different scenarios including clinical case studies· Critically understand the experimental approaches used to capture the evidence.· Harness this knowledge to devise more effective and precise therapeutics
