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所在平台: Udemy |
课程主页: https://www.udemy.com/course/full-guidance-on-amino-acidprotein-databases-for-beginners/
课程评论：没有评论
课程名称：初学者的氨基酸/蛋白质数据库全面指导 概述：这门生物信息学课程将为您带来重大变化。目前，生物数据的激增使得生物信息学处于生物学与计算机科学的交叉点。生物信息学是指使用计算机存储、检索、分析或预测生物分子的组成或结构。它是将计算技术和信息技术应用于生物数据的组织和管理。传统的生物信息学主要集中在序列分析方面。 生物信息学的目标： - 开发包含所有生物信息的数据库。 - 开发更好的数据设计、注释和挖掘工具。 - 利用模拟软件设计和开发药物。 - 设计和开发蛋白质结构预测、功能、注释和对接分析的软件工具。 - 创建和开发软件以改进序列功能和相似性的分析工具。 生物数据库： 生物数据通常是复杂的、例外频出的、庞大的和不完整的。因此，已创建多个数据库来确保明确的结果。生物数据库是以计算机可读的形式来组织生物数据，从而提高搜索和检索的速度并方便使用的集合。良好的数据库必须具有最新的信息。 生物数据库的重要性： 可以通过生物数据库检索到生物序列、结构、结合位点、代谢相互作用、分子作用、功能关系、蛋白质家族、基序和同源等一系列信息。生物数据库的主要目的是存储和管理生物数据与信息，以便于计算机阅读形式进行访问。 在这门课程中，我们学习了生物信息学中使用的不同生物数据库，并了解到它们的一些细节。这些数据库主要分为四个类别，我们逐一进行了解，并解释了主数据库和次数据库之间的区别以及它们在生物信息学中的应用。 氨基酸/蛋白质数据库： 现已开发出多种公共数据存储库和资源，以支持和管理与蛋白质相关的信息、生物知识的发现及数据驱动的假设生成。课上介绍的数据库主要来自《核酸研究》期刊的数据库问题及数据库集，以及在UniProtKB中交叉引用的数据库。大多数数据库与UniProt/UniProtKB交叉引用，以便可以相互映射标识符。 这门课程将极大地帮助数据分析师和生物信息学学生，因为他们在工作中频繁使用这些数据库。如有任何问题或建议，请通过讲师邮箱与我联系，我会在12小时内尝试回答所有问题。
This Bioinformatics course is going to game changer for you. Currently, there is an explosion of biological data. Bioinformatics is at the intersection of biology and computer science.What is Bioinformatics ?In biology, bioinformatics is defined as, "the use of computer to store, retrieve, analyze or predict the composition or structure of bio-molecules". Bioinformatics is the application of computational techniques and information technology to the organization and management of biological data. Classical bioinformatics deals primarily with sequence analysis.Aims of BioinformaticsDevelopment of database containing all biological information.Development of better tools for data designing, annotation and mining.Design and development of drugs by using simulation software.Design and development of software tools for protein structure prediction function, annotation and docking analysis.Creation and development of software to improve tools for analyzing sequences for their function and similarity with other sequencesBiological DatabasesBiological data are complex, exception-ridden, vast, and incomplete. Therefore several databases have been created and interpreted to ensure unambiguous results. A collection of biological data arranged in a computer-readable form that enhances the speed of search and retrieval and convenient to use is called a biological database. A good database must have updated information.Importance of Biological DatabaseA range of information like biological sequences, structures, binding sites, metabolic interactions, molecular action, functional relationships, protein families, motifs and homologous can be retrieved by using biological databases. The main purpose of a biological database is to store and manage biological data and information in computer readable forms.In this course we learned about the different biological databases that are being used in bioinformatics and get to know a little bit about their details. Mainly these databases are divided into four categories and we learned about them base by base. And explained the difference among the primary and secondary database and explained their utilization in bioinformatics.Amino acid / protein databasesSeveral publicly available data repositories and resources have been developed to support and manage protein related information, biological knowledge discovery and data-driven hypothesis generation. The databases in the table below are selected from the databases listed in the Nucleic Acids Research (NAR) databases issues and database collection and the databases cross-referenced in the UniProtKB. Most of these databases are cross-referenced with UniProt / UniProtKB so that identifiers can be mapped to each other. Sequence databasesCCDS The Consensus CDS protein set database DDB JDNA Data Bank of JapanENA European Nucleotide ArchiveGenBank GenBank nucleotide sequence databaseRefseq NCBI Reference Sequence DatabaseUniGene Database of computationally identifies transcripts from the same locus UniProtKB Universal Protein Resource (UniProt) 3D structure protein databasesDisProt Database of Protein DisorderMobiDB Database of intrinsically disordered and mobile proteinsModBase Database of Comparative Protein Structure ModelsPDBsum Pictorial database of 3D structures in the Protein Data BankProteinModelPortal Protein Model Portal of the PSI-Nature Structural Biology KnowledgebaseSMR Database of annotated 3D protein structure modelsThis course will be extremely helpful to students of data analyst and bioinformaticians because they use the databases a lot in their work.If you guys have any questions or suggestions please let me know in instructor inbox I'll try to answer all of your questions within 12 hours.
