|
所在平台: Udemy |
课程主页: https://www.udemy.com/course/critical-appraisal-of-clinical-trials/
课程评论：没有评论
课程名称：临床试验的批判性评价 课程概述：本课程旨在帮助学习者提高对健康科学文献中临床试验的医疗干预证据进行批判性评价和应用的能力。课程将全面回顾临床试验的各个方面，包括： 1. 协议的重要性及其在试验前、期间或完成后变更的影响。 2. 参与者招募和入组的多种方法，包括富集和其他适应性设计。 3. 随机化的重要性及确保随机化有效的方法。 4. 随机化过程中的分配隐蔽性的重要性。 5. 在试验过程中盲法的重要性，包括对患者、研究者、分析员和监控者的盲法，以及在某些情况下盲法对研究有效性的重要性。 6. 高层次的数据分析方法及文献中常见的陷阱。 7. 缺失数据和失访对试验结果有效性的影响。 8. 计划交叉试验的概念。 9. 其他试验设计，包括非劣效试验，确保试验不误判两种干预措施相似性的情况。 此外，课程还将提供两节额外讲座。第一节讲座旨在将临床试验的结果应用于个体患者。第二节讲座将介绍观察性研究，讨论其与随机对照试验的差异以及观察性研究中的常见陷阱。 本课程将帮助学员更深刻地理解和评估临床试验，提升其在医疗领域的应用能力。
This course is intended to help learners improve their ability to critically appraise and apply evidence about healthcare interventions derived from clinical trials appearing in the health sciences literature. The course will review all aspects of clinical trials including:1) The importance of protocols and changes in protocols before, during or after the trial is completed2) Various ways that participants will be recruited and enrolled in the trial, including enrichment and other adaptative design3) The importance of randomization and how to ensure randomization worked within a clinical trial4) The importance of allocation concealment during the randomization process5) The importance of blinding participants during the conduct of the trial including patients, investigators, analysts, and monitors. Will also discuss instances where blinding may be more or less important in the validity of the study6) Review high-level approaches to analyzing the data and common pitfalls made in the literature7) Discuss the impact that missing data and losses to follow-up have on the validity of trial results8) Review the concept of planned cross-over trials9) Review additional trial designs including non-inferiority trials and how to ensure a trial does not make a false claim that two interventions are similar when in fact they are not.In addition to the lectures on understanding and appraising clinical trials, two bonus lectures will be provided. The first is aimed at taking results from clinical trials and introducing the concept of how to apply results to individual patients. The second bonus lecture will introduce observational research, how it differs from randomized controlled trials, and common pitfalls in many observational research conducted in health.
