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所在平台: Udemy |
课程主页: https://www.udemy.com/course/computer-aided-drug-design-cadd-comprehensive-course/
课程评论：没有评论
**Coursera 课程总结：从 A 到 Z 的计算机辅助药物设计 (CADD)** 本课程是关于计算机辅助药物设计 (CADD) 的综合性入门课程，旨在帮助学员从零开始设计药物。课程内容涵盖药物发现的各个方面，从基础概念到实践操作，理论与实践并重。 **课程目标：** * 了解药物发现的不同来源和先导化合物的获取途径。 * 掌握药物优化和开发的各种方法。 * 理解药物在分子层面的作用机制。 * 阐明药物的物理化学性质与其生物活性之间的关系。 * 熟悉药物与各类受体之间的相互作用。 * 了解药物与受体之间相互作用的类型。 * 掌握现代药物设计技术，包括： * 基于计算机的定量结构-活性关系 (QSAR) 方法。 * 分子图形学。 * 学习使用 MOE 程序进行分子对接（包含实践部分）。 **课程内容概览：** 1. **引言** 2. **药物发现中的先导化合物来源** 3. **先导化合物优化方法** 4. **改善药物的物理化学性质** 5. **激动剂或拮抗剂的设计** 6. **药物前药（Prodrug）设计** 7. **药物-受体相互作用的治疗学方面** 8. **结构（空间）特征与药理活性** 9. **药物活性成分的分类** 10. **定量结构-活性关系 (QSAR)** 11. **分子动力学模拟** 12. **连接理化参数与生物活性的方法** 13. **药物设计中的分子建模** 14. **使用 MOE 程序进行对接（实践部分）** **适合人群：** 本课程适合任何希望了解药物创建过程、学习药物设计，或从零开始学习分子对接的学员。 **特别提示：** 课程提供 MOE 程序下载链接。
this course is comprehensive as it include all the basics and concepts of drug discovery. After obtaining this course you will be able to easily design your drug from the scratch.if you want to understand the concepts and practice the steps with the most comprehensive Computer-aided drug design course join it now, the course contains theoretical and practical illustration for all concepts of drug discovery.the course is suitable for anyone wants to know and understand the first creation of the drugs and their awesome designing.this course is for anyone wants to learn molecular docking from scratch.the course objectives:Knowing the different sources of drug discovery and lead compound ways.Knowing all the different methods of drug optimization and development.Understanding how drugs function at the molecular level.Understanding the relationships between physico-chemical properties of drugs and their biological activities.Knowing how drugs interact with receptors of different kinds.Knowing the types of interactions between drugs and receptors.Be familiar with the modern techniques in the field of drug design such as: -Computer based methods of quantitative structural activity relationship QSAR. -Molecular graphics.Knowing the process of docking using MOE program.course contents:1.Introduction.2.Sources of lead compound in drug discovery.3.methods of Lead optimization.4.Improvement of drug physiochemical properties.5. Design of drug agonist or antagonist.6.Drug latentiation (prodrug).7.Therapeutic aspects of drug-receptor interaction.8.Structural (steric) features and pharmacological activity.9.Classification of drug active ingredients.10.Quantitative structural activity relationship QSAR.11. molecular dynamics simulations12.Methods used to correlate physicochemical parameters and biological activity.13.Molecular modeling in drug design.14.Docking using MOE program (practical part). CONTACT ME TO GET MOE PROGRAM AS DRIVE LINK READY TO DOWNLOAD
