|
所在平台: Udemy |
课程主页: https://www.udemy.com/course/cheminformatics-and-medicinal-chemistry/
课程评论：没有评论
**课程名称：** 计算化学与药物化学导论 **课程概述：** 本课程将介绍计算化学和药物化学的核心概念和实用工具，特别关注其在药物发现领域的应用。 计算化学是一门融合了化学理论和信息学应用的交叉学科，广泛应用于药物开发、环境科学和材料科学等领域。本课程将聚焦于计算化学在药物发现中的具体应用。您将学习如何使用化学数据库，绘制分子结构，并掌握分析分子理化性质和结构特征的软件，从而预测药物的药代动力学特性、生物活性或安全性。 药物化学是化学与药理学的交叉领域，直接参与理性药物开发过程。与传统药物发现过程不同，药物化学强调对化合物的化学性质和结构的研究，以深入理解其生物活性。因此，药物化学能够基于官能团、分子量、cLogP等信息，为选择分子、预测其药代动力学（如血药浓度）或生物活性提供理论依据。 **您将获得的知识：** * 了解分子如何以线性文件格式表示。 * 学习如何使用化学数据库。 * 掌握有助于预测药物口服生物利用度的理化特征。 * 使用免费软件分析分子结构，预测其理化特征。 * 使用免费软件分析分子结构，预测其生物活性。 * 理解蛋白质在药物发现过程中的作用。 * 通过参与Foldit游戏，为生物化学和蛋白质设计领域做出贡献。
Hi! In this course, I'm going to introduce some concepts and tools of Medicinal Chemistry and Cheminformatics! Cheminformatics can be understood as an interdisciplinary field. It encompasses the theoretical knowledge of chemistry and the application of informatics. This area is applied in several fields, such as drug development, environmental science, and material science. In this course, we are going to focus on the part of cheminformatics applied to drug discovery. In this introductory course, you'll gain knowledge of chemical databases, drawing of molecular structures, and softwares to analyze physicochemical and structural features of molecules to predict their pharmacokinetic properties, bioactivity, or safety profile.Medicinal chemistry, on the other hand, is an area where chemistry and pharmacology intersect, and it is directly involved in the process of rational drug development. Its main difference from the traditional drug discovery process is the emphasis on the chemical properties and structure of the chemical compounds investigated to generate possible insights into their biological activities. Medicinal chemistry, therefore, provides the rationale for choosing molecules, deducing their possible pharmacokinetic properties, such as plasma concentration, or biological activity, based on their functional groups, molecular weight, cLogP, etc. You may like this course if you are interested in...Understanding how molecules can be represented in a linear format fileKnowing how to use chemical databasesKnowing about physicochemical features that may help to predict oral availability of drug candidatesUsing free softwares to analyze the structure of molecules to predict physicochemical featuresUsing free softwares to analyze the structure of molecules to predict biological activityKnowing how proteins are relevant to the process of drug discoveryContributing to the field of biochemistry and protein design by playing Foldit
