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课程名称：生物信息学为生物学家（5天课程） 课程概述： 本课程适合未曾在大学层面学习生物信息学的学生，旨在帮助生物学家了解如何利用生物信息学工具在各自的领域（如生物化学、生物技术、分子生物学、植物学和动物学）中进行应用。生物信息学主要分析基因组数据，关注DNA和基因组的研究。生物体的全部遗传信息被称为基因组，正如弗朗西斯·塞勒斯·柯林斯所言，基因组是上帝所写的语言（2006年）。在课程中，学生将探索基因组数据库、进行计算实验室的基因组数据分析，以及多重序列比对和系统发育分析。这些实验将促进基因组学的实施。本课程是深造课程（如基因组学、癌症基因组学、进化论或分子生物学）的优秀补充。通过了解基因组学和生物信息学的最新概念及技术，学生将能够对基因组学的进展及其社会影响发展批判性思维。课程将提供现代基因组学和生物信息学概念及科学方法的扎实理解，特别应用于人类研究。 课程目标： 本课程的目标是为学生提供生物信息学基本概念及其应用的导向。 课程大纲： - 生物信息学基本概念 - 所有生物体的基础遗传学 - 数据库 - BLAST（基本本地比对搜索工具） - 同源性 - 系统发育分析 所需教材： - Jonathan Pevsner的《生物信息学与功能基因组学》（第二版），Wiley-Liss，ISBN# 978-0-470-08585 - Arthur M. Lesk的《基因组学导论》，牛津大学出版社，2007年 - Sandy B. Primrose和Richard Twyman的《基因组分析原理与基因组学》（第三版），Blackwell Publishing，2008年。
IntroductionThis course is for students who have not studied Bioinformatics at the University level. The basic concepts of Bioinformatics course is to help all Biologist how to use Bioinformatics tools for their fields e.g: Biochemistry, Biotechnology, Molecular Biology, Botany, Zoology. Bioinformatics analyze the Genomics data.Which has always been concerned with the DNA and genome. The total genetic information of an organism is known as the genome. The genome of an organism is written by God (Francis Sellers Collins, 2006), so let's explore the language of God. During this course, students will explore genome databases, genomic data analysis in the computational lab, and multiple sequence alignment and phylogeny. These experiments provide the implementation of genomics. This course is an excellent accompaniment to postgraduate courses of specializing like genomics, cancer genomics, evolution, or molecular biology. By learning all new concepts and techniques about genomics and Bioinformatics, students can develop critical thinking about advances in genomics and their social implications. This course provides a solid understanding of the concepts and scientific methods of modern genomics and Bioinformatics which applies to humans.ObjectivesThe objective of this course is to provide an orientation to the students about the basic concepts of Bioinformatics and its applications.Course OutlineBasic concepts Bioinformatics•Basics Genetics of all organism•Database•BLAST•Homology•Phylogenetic analysisRequired TextBioinformatics and Functional Genomics (2nd edition) by Jonathan Pevsner,Wiley-Liss, ISBN# 978-0-470-08585· Introduction to Genomics by Arthur M. Lesk, Oxford University Press, 2007Principles of Genome Analysis and Genomics (Third Edition) Sandy B. Primrose and Richard Twyman, Blackwell Publishing, 2008.
