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所在平台: Udemy |
课程主页: https://www.udemy.com/course/basics-of-medicinal-chemistry/
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**课程名称：** 药物化学基础 **课程概述：** 本课程深入介绍药物化学，这是一门融合了化学（特别是合成有机化学）与药理学及多种生物学分支领域的交叉学科。药物化学专注于药物活性分子（药物）的设计、化学合成以及市场开发。 课程内容涵盖： * **药物分类：** 重点介绍药物通常是有机化合物，并将其分为小分子有机化合物（如阿托伐他汀、氟替卡松、氯吡格雷）和生物制品（如英夫利昔单抗、促红细胞生成素、甘精胰岛素）。此外，无机和有机金属化合物（如碳酸锂、顺铂、镓）也作为药物有其应用。 * **药物化学实践：** 侧重于小分子有机化合物的药物化学，强调合成有机化学、天然产物化学和计算化学与化学生物学、酶学及结构生物学的紧密结合，旨在发现和开发新的治疗药物。这包括对新化学实体进行系统的、彻底的化学修饰，使其适于治疗用途。 * **结构-活性关系（SAR）：** 探索现有药物和在研药物与生物活性（药理作用和性质）之间的关系，重点在于理解其结构-活性关系（SAR）。 * **质量与配方：** 药物化学关注药品的质量方面，确保药品的适用性。 * **跨学科合作：** 药物化学与其他学科如生物化学、分子生物学、药用植物学、药理学、毒理学、兽医学和人类医学，以及项目管理、统计学和制药商业实践等共同协作，旨在系统性地改造已识别的化学试剂，使其在经过药物制剂后，安全有效，适用于疾病治疗。 **核心目标：** 本课程旨在使学习者了解药物化学的基本概念。
Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs). Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant antibodies, hormones etc.). Inorganic and organometallic compounds are also useful as drugs (e.g., lithium and platinum-based agents such as lithium carbonate and cisplatin as well as gallium).In particular, medicinal chemistry in its most common practice-focusing on small organic molecules-encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents. Practically speaking, it involves chemical aspects of identification, and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use. It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for purpose of medicinal products.At the biological interface, medicinal chemistry combines to form a set of highly interdisciplinary sciences, setting its organic, physical, and computational emphases alongside biological areas such as biochemistry, molecular biology, pharmacognosy and pharmacology, toxicology and veterinary and human medicine; these, with project management, statistics, and pharmaceutical business practices, systematically oversee altering identified chemical agents such that after pharmaceutical formulation, they are safe and efficacious, and therefore suitable for use in treatment of disease.This course enables the learner to be aware of basic concepts of medicinal chemistry.
