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所在平台: Udemy |
课程主页: https://www.udemy.com/course/anecdotes-in-cancer-biology/
课程评论：没有评论
**课程名称：** 重组DNA技术——癌症生物学中的变革者 **课程概述：** 本课程深入探讨癌症生物学的历史发展，重点关注理解癌变过程所提出的各项理论和克隆策略。课程旨在带领学员回顾那些关键性的时刻，诸如化学致癌物、逆转录病毒和染色体突变等重要发现如何共同揭示了癌症的宏大图景，并提出癌症发生的潜在标准。 课程亮点在于对20世纪60年代至90年代期间发展起来的实验方法的介绍，这些方法为我们今天所理解的癌症模型奠定了基础，该模型源自两个核心概念——**癌基因（oncogenes）**和**肿瘤抑制基因（tumor suppressor genes）**。 **您将学习到：** * **化学理论：** 癌症的形成机制，包括体细胞突变假说（somatic mutation hypothesis）和Ames试验。 * **染色体理论：** 证明染色体畸变导致癌症的实验。 * **病毒理论：** 涉及Rous肉瘤病毒、前病毒理论（pro-viral theory）、逆转录酶（reverse transcriptase）的发现以及白血病发生理论（Leukemogenesis theory）。 * **癌基因与突变机制：** 揭示原癌基因（proto-oncogenes）存在的实验，以及癌症细胞中发生的各种突变机制。 * **肿瘤抑制基因：** 类比将癌基因比作汽车的“加速器”，而肿瘤抑制基因则如同“刹车”。您将了解细胞融合实验（cell fusion experiment）、Knudson假说（Knudson hypothesis）以及杂合性丢失（loss of heterozygosity）。 * **重要蛋白的发现：** 学习“基因组守护者”p53和pRb等肿瘤抑制基因的发现过程。 **总结：** 本课程通过回顾重组DNA技术在癌症生物学领域的发展历程，清晰地阐述了癌症发生的基本原理，特别是癌基因和肿瘤抑制基因在其中扮演的关键角色。通过对历史性实验的深入剖析，学员将对癌症的起源、发展机制以及相关的治疗策略获得更深刻的理解。
This course on cancer biology focuses on historical theories and cloning strategies put forth to comprehend carcinogenesis. The objective is to travel back in time to the period when all the pieces of puzzle such as chemical carcinogens, retroviruses and chromosomal mutations came together to reveal the grand scheme of cancer and propose the underlying criteria for cancer development. The highlights of this lecture series are the experimental methods developed during 1960s to 1990s which built the foundation for the current model of cancer which stems from two concepts namely- oncogenes and tumor suppressor genes.You'll learn about Ames test, pro-viral theory, the discovery of reverse transcriptase, Leukemogenesis theory, different mechanisms of tumor cell mutations occurring in the cells, knudson hypothesis and much more.You'll learn-Chemical theory section explains the formation of cancer. Somatic mutation hypothesis and Ames test are concepts covered under chemical theoryChromosomal theory section covers the experiments done to show that chromosomal aberrations cause cancer.Viral theory section deals with Rous sarcoma virus, pro-viral theory, the discovery of reverse transcriptase, Leukemogenesis theory.The experiments that indicated the presence of proto-oncogenes and different mechanisms of mutations occurring in cancer cells.If oncogenes are like accelerators in the car, then tumor suppressors are like brakes. Learn about the cell fusion experiment, Knudson hypothesis and loss of heterozygosity.How p53 (the guardian of the genome) and pRb tumor suppressors were discovered.As is with any course, this course is also backed by Udemy's 30 day money back guarantee.If you're not happy for any reason you will get a full refund.So take this course today, and get deeper insights in cancer biology.
