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所在平台: Udemy |
课程主页: https://www.udemy.com/course/all-about-lyme-disease/
课程评论：没有评论
**课程名称：** 莱姆病全解析（All about Lyme Disease） **课程概述：** 本课程深入探讨了莱姆病，这是美国第二常见的媒介传播疾病（仅次于西尼罗河病毒病）。课程将带您了解研究莱姆病的重要性，并回顾其在康涅狄格州莱姆镇首次被发现的背景。 课程内容涵盖了莱姆病的三种主要临床表现：早期阶段常出现的“靶心”皮疹，以及晚期更常见于患者的莱姆关节炎。作为一种由蜱虫传播的细菌感染，课程详细介绍了传播媒介——蜱虫的生命周期，以及引起莱姆病的细菌。特别地，课程会阐述细菌在从蜱虫传播给人或其他宿主的过程中，以及反向传播时，其细菌表面会发生怎样的变化。 课程还专门介绍了莱姆病的病原体——伯氏疏螺旋体（Borrelia burgdorferi），这是一种独特的革兰氏阴性螺旋体细菌。 在诊断方面，除了临床诊断，课程依照美国疾病控制与预防中心（CDC）的标准，分步骤详细介绍了ELISA、IFA和Western Blot等实验室诊断方法。 治疗方面，课程将解释首选的抗生素治疗方案，并讨论在完整治疗后仍可能出现的持续性临床表现。 最后，课程将讨论主要的预防方法，并解释为何伯氏疏螺旋体能够快速改变其表面脂蛋白的表达，从而给疫苗的开发带来挑战。
This Course is focused on Lyme disease, that is second most common vector-borne disease in the US, the first being West Nile Virus disease. In the Course, you will have an understanding of the importance of studying Lyme disease and a background knowledge of how the first cases of the disease were detected in Lyme, Connecticut. The Course content also involves description of the three clinical manifestations of the disease, of which the "bull's eye" rash is typically found in quite a few patients at early stages and Lyme arthritis is most commonly encountered at a later stage of the disease. Since it is a tick-borne bacterial infection, the course also mentions the tick, the tick life cycle and the bacteria, along with the changes that occur on the bacterial surface as it is transmitted from tick to humans (or other hosts) and vice-versa. Being a spirochete, which is a unique Gram-negative bacteria, a description of Borrelia burgdorferi, the agent of Lyme disease, is also provided. Apart from clinical diagnosis, a laboratory diagnosis, according to CDC with step-by-step procedures for ELISA, IFA and Western Blot are provided. In the Course, there is also explanation of the antibiotics of choice for treatment and cases of lingering clinical manifestations in spite of a complete therapy. At the very end, the main prevention methods available, along with the challenges of vaccination due to the ability of Borrelia to rapidly change the expression of its surface lipoproteins is also discussed.
