开始时间: 04/22/2022 持续时间: 未知
所在平台: MIT公开课 课程类别: 生物与生命科学 大学或机构: ocw |
课程评论:没有评论
In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.