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Analyze your Genome!

所在平台: EdxArchive

课程类别: 其他类别

大学或机构: UC San DiegoX

授课老师： Phillip Compeau Niema Moshiri Pavel Pevzner

课程主页: https://www.edx.org/archive/analyze-genome-uc-san-diegox-binf180-1

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课程简介

Learn how to use existing tools and pipelines to analyze next generation sequencing (NGS) data.

课程大纲

  • How to reconstruct a genome by stringing together its tiny fragments using popular genome assembly tools to sequence a pathogen
  • How to find mutations in your genome and how to test whether they are linked to genetic diseases.
  • Investigate the genetic makeup of a "trio" (mother, father, and child) to figure out whether the child inherited the disease from the parents or unluckily developed the genetic disease through de novo mutations
  • How to analyze gene expressions
  • How to investigate what genes are turned on or off in various tissues in order to figure out which genes are important for each cell type and which genes are over-expressed in cancer and other diseases.

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课程详情

Are you interested in analyzing biological datasets but don’t have a strong computational background? Do you want to focus on the biology and learn how to use modern best-practice pipelines that use existing tools? This introductory course, geared towards non-computational biologists, will introduce a specific biological problem each week centered around next generation sequencing and teach you how to use Illumina’s BaseSpace platform to run workflows conveniently and in a user-friendly manner.

You will learn current best-practice workflows for Genome Assembly, Variant Calling, Trio Analysis, and Differential Expression Analysis as well as the types of biological problems that motivate them.

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