Medicinal Chemistry: The Molecular Basis of Drug Discovery

开始时间: 04/22/2022 持续时间: 8 weeks

所在平台: EdxArchive 课程类别: 其他类别 大学或机构: davidsonx 授课老师： Allison Dulin Erland Stevens

课程主页: https://www.edx.org/archive/medicinal-chemistry-molecular-basis-drug-davidsonx-d001x

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课程详情

*Note - This is an Archived course*

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This course explores how to bring a drug from concept to market, and how a drug's chemical structure relates to its biological function. The course opens with an introduction to the drug approval process. This introduction combines the social, economic, and ethical aspects of drug discovery. Topics include how diseases are selected for treatment, the role of animal testing, and the costs of various discovery phases. The course then focuses on the scientific side of drug discovery. Topics include how drugs interact with biological molecules, drug absorption and elimination, and the discovery of weakly active molecules and their optimization into viable drugs.

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This is a past/archived course. At this time, you can only explore this course in a self-paced fashion. Certain features of this course may not be active, but many people enjoy watching the videos and working with the materials. Make sure to check for reruns of this course.

课程大纲

• The types and functions of biological molecules most frequently targeted by drugs
• Methods for modeling pharmacokinetic parameters, including half-life and volume of distribution
• How to predict and alter the metabolism of a molecule
• Techniques for discovering and prioritizing new molecules with activity against a desired target
• Approaches for optimizing a molecule’s properties to increase its chances of becoming a drug

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