How Viruses Cause Disease

开始时间: 04/22/2022 持续时间: 12 weeks

所在平台: CourseraArchive

课程类别: 医学

大学或机构: Columbia University(哥伦比亚大学)

授课老师: Vincent Racaniello

课程主页: https://www.coursera.org/course/virology2

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课程详情

This introductory virology course explores the interplay between viruses and their host organisms. The course begins with an overview of how infection is established in a host, then moves to a virologist's view of immune defenses.  Next we consider how the replication strategy and the host response determine the outcome of infection, such that some are short and others are of long duration. The mechanisms by which virus infections transform cells in culture are explored, a process that may lead to tumor formation in animals. We then move to a discussion of how viral infections are controlled by vaccines and antiviral drugs. After an introduction to viral evolution, we discuss the principles learned from zoonotic infections, emerging infections, and humankind's experiences with epidemic and pandemic viral infections. The course ends with an exploration of unusual infectious agents such as viroids, satellites, and prions, followed by a discussion of the causative agent of the most serious current worldwide epidemic, HIV-1.

课程大纲

Week 1
Infection basics
Entry into the host
Viral spread
Tissue invasion and tropism
Transmission and seasonality
Week 2
Innate immune responses
Interferon
Sentinels and complement
Inflammation
Adaptive immunity
Week 3
Viral virulence
Mechanisms of cell injury I
Mechanisms of cell injury II
Host susceptibility
Week 4
Acute infections
Influenza
Poliomyelitis
Measles
Gastroenteritis
West Nile fever
Week 5
Persistent infections
Week 6
Transformation and oncogenesis
Week 7
Vaccines
Week 8
Antivirals
Week 9
Evolution
Week 10
Emerging viruses
Week 11
Unusual infectious agents
Week 12
HIV pathogenesis

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课程简介

Introductory virology course that covers the interplay between viruses and their host organisms, with with the goal of understanding viral diseases and their prevention.

课程标签

病毒 哥伦比亚大学

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