开始时间: 04/22/2022 持续时间: 5 weeks
所在平台: CourseraArchive 课程类别: 信息,技术与设计 大学或机构: Johns Hopkins University(约翰•霍普金斯大学) 授课老师: Bob Lessick |
课程主页: https://www.coursera.org/course/bioinform
课程评论:没有评论
The DNA sequencing revolution has exploded and new, inexpensive technologies have led to sequences being determined faster than they can be analyzed. Bioinformatics brings together biology, math and computer science into a quickly emerging discipline that turns the computer into a scientific research lab.
The relevance of bioinformatics extends to many disciplines, including health science, molecular biology, genetics, drug discovery, biochemistry, cell biology and education. Its impact is significant. Many scientific researchers with advanced degrees are going back to school to learn computer techniques that have become as essential to new discovery as pipettes and flasks.
This course will introduce some important basic bioinformatics concepts while allowing for the adventurous to explore some topics in further depth if desired.
Week 1: Biological Databases
· Database Structure
· Searching PubMed
· The NCBI Public Sequence Database
· Sequence Retrieval
Week 2 - BLAST and Sequence Alignment
· Pairwise Sequence Alignment
· BLAST, Database Searches
· Assessing Homology
Week 3 – Protein Bioinformatics
· Determining Molecular Weight, Isoelectric Point
· Predicting Secondary Structure
· The PDB Database
· Prosite Domain searches
· Predicting Cellular Localization
Week 4 – Prokaryotic Genomes
· Bacterial Gene Prediction
· Prokaryotic Gene Structure
· Viruses
Week 5 – Eukaryotic Genomes, Human Variation
· Eukaryotic Gene Structure
· Ensembl Database
· Single Nucleotide Polymorphisms
· DNA Fingerprinting
What makes bioinformatics education exciting is that people of a variety of education levels can get started quickly, with just a computer and internet access.