Industrial Biotechnology

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课程主页: https://www.coursera.org/archive/industrial-biotech

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University of Manchester

课程大纲

Enzyme catalysts are central to life. They are the vehicles for delivering innovative bioscience solutions to chemicals manufacture, drug discovery, therapeutics and bioprocessing. They are the key enablers in the white biotechnology revolution, providing essential components in the new science of 'synthetic biology', offering new routes to biofuels, bulk and commodity chemicals and novel therapeutics.

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课程详情

Fossil fuels have been the primary energy source for society since the Industrial Revolution. They provide the raw material for the manufacture of many everyday products that we take for granted, including pharmaceuticals, food and drink, materials, plastics and personal care. As the 21st century progresses we need solutions for the manufacture of chemicals that are smarter, more predictable and more sustainable. Industrial biotechnology is changing how we manufacture chemicals and materials, as well as providing us with a source of renewable energy. It is at the core of sustainable manufacturing processes and an attractive alternative to traditional manufacturing technologies to commercially advance and transform priority industrial sectors yielding more and more viable solutions for our environment in the form of new chemicals, new materials and bioenergy. This course will cover the key enabling technologies that underpin biotechnology research including enzyme discovery and engineering, systems and synthetic biology and biochemical and process engineering. Much of this material will be delivered through lectures to ensure that you have a solid foundation in these key areas. We will also consider the wider issues involved in sustainable manufacturing including responsible research innovation and bioethics. In the second part of the course we will look at how these technologies translate into real world applications which benefit society and impact our everyday lives. This will include input from our industry stakeholders and collaborators working in the pharmaceutical, chemicals and biofuels industries. By the end of this course you will be able to: 1. Understand enzymatic function and catalysis. 2. Explain the technologies and methodologies underpinning systems and synthetic biology. 3. Explain the diversity of synthetic biology application and discuss the different ethical and regulatory/governance challenges involved in this research. 4. Understand the principles and role of bioprocessing and biochemical engineering in industrial biotechnology. 5. Have an informed discussion of the key enabling technologies underpinning research in industrial biotechnology 6. Give examples of industrial biotechnology products and processes and their application in healthcare, agriculture, fine chemicals, energy and the environment.

工业生物技术:自工业革命以来,化石燃料一直是社会的主要能源。它们为制造我们认为理所当然的许多日常产品提供了原材料,包括药品,食品和饮料,材料,塑料和个人护理。 随着21世纪的发展,我们需要更智能,更可预测和更可持续的化学品制造解决方案。 工业生物技术正在改变我们制造化学品和材料的方式,以及为我们提供可再生能源的方式。它是可持续制造过程的核心,并且是传统制造技术的一种有吸引力的替代方案,可以使商业发展和转变优先工业领域,从而以新化学,新材料和生物能源的形式为我们的环境提供越来越多可行的解决方案。 本课程将涵盖支持生物技术研究的关键使能技术,包括酶发现和工程,系统和合成生物学以及生化和过程工程。这些材料大部分将通过讲座提供,以确保您在这些关键领域具有坚实的基础。我们还将考虑可持续制造涉及的广泛问题,包括负责任的研究创新和生物伦理。 在课程的第二部分中,我们将研究这些技术如何转化为对社会有益并影响我们日常生活的现实应用。这将包括我们在制药,化学和生物燃料行业的行业利益相关者和合作者的投入。 在本课程结束时,您将能够: 1.了解酶的功能和催化作用。 2.解释支撑系统和合成生物学的技术和方法。 3.解释合成生物学应用的多样性,并讨论本研究涉及的不同伦理和监管/治理挑战。 4.了解生物加工和生化工程在工业生物技术中的原理和作用。 5.对支持工业生物技术研究的关键使能技术进行有见地的讨论 6.举例说明工业生物技术产品和工艺及其在医疗保健,农业,精细化工,能源和环境中的应用。

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