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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/toxicology-21
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《毒理学21：科学应用》课程介绍 本课程旨在让学生了解新兴概念，以应对国家研究委员会的突破性报告《21世纪的毒性测试：愿景与战略》，并更新监管毒理学。课程呈现了毒理学领域的最新进展，重点关注从动物测试向与人类相关的高内容、高通量整合测试策略的转变。美国环境保护局（EPA）、国家卫生研究院（NIH）以及全球科学界的活跃项目展示了安全科学的动态变化。 课程大纲： 模块1：本模块广泛介绍21世纪毒理学（Tox21c）领域，并熟悉主要文件，总结Tox21c的主要思想和原则。 模块2：讨论ToxCast和Tox21技术在实践中的应用，详细介绍EPA内分泌干扰物筛查程序，并展示ToxCast平台如何取代传统的体内分级方法，加速了过程的进展。此外，还将讨论用于毒性测试的计算模型发展。 模块3：介绍约翰霍普金斯大学主导的人类毒组计划，并与多个大学、行业和研究机构合作。讨论组学技术的优缺点，以及不良结果途径（AOP）和毒性途径（PoT）的概念。 模块4：解释“相似测试”概念及其对监管风险评估的重要性，以及如何根据REACH法规在行业中实施。此外，将学习现有的体外细胞模型，从简单的单层细胞培养到复杂的器官芯片（organ-on-a-chip）和人类芯片（human-on-a-chip）方法。 模块5：学习miRNA和表观遗传学在毒理学和环境健康中的作用。 模块6：了解体外毒理学的重要组成部分，如体外到体内的外推（IVIVE）和生理基础生物动力学建模。学习为何在体外考虑生物动力学重要，并查看一些体外生物动力学建模的示例。同时，还将介绍大数据分析的方法。 模块7：学习综合测试策略及其与单个测试或测试电池的不同之处。最后一节“超越化学”将总结你在本课程中的知识，并展望替代动物测试领域的未来方向。
Name:Module 1
Description:This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c.
Name:Module 2
Description:This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.
Name:Module 3
Description:This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed.
Name:Module 4
Description:The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.
Name:Module 5
Description:This module will teach you the role of miRNA and epigenetics in toxicology and environmental health.
Name:Module 6
Description:In this module you will learn about important component of in vitro toxicology such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modeling. You will learn why it is important to consider biokinetics in vitro and see some example of biokinetics modeling in vitro. This lesson will also give you a biometry prospective of in vitro toxicology. You will learn which methods can be used to analyze big data.
Name:Module 7
Description:In this lesson you will learn about integrated testing strategies and how they differ from individual tests or test batteries. Also a wrap-up lesson "beyond chemical" will summaries your knowledge from this course and give a out-look for further directions in the field of alternatives to animal testing.
This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.
