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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/targets-assays-screening
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课程名称：靶点、测定与筛选 课程概述：本课程重点关注药物发现的早期阶段，着重于识别有前景的化合物，以便开始寻找新型药物。课程回顾了用于筛选分子库的不同类型的测定和方法，以便在初步搜索中找到具有活性的化合物。课程还讨论了如何验证活性分子确实与预测具有治疗益处的靶点相互作用的方法。 目标受众：本课程适合生命科学领域的从业者。 课程大纲： - 名称：靶点、测定与筛选，第一部分 描述：欢迎您参加本课程，课程结束后，学生将能够：识别靶向药物发现与表型药物发现之间的差异。区分常见的分库类型和筛选方法，以确定小分子化合物的命中。描述一些用于早期筛选的测定类型以及在设计时需要考虑的因素。 - 名称：靶点、测定与筛选，第二部分 描述：待定。 - 名称：靶点、测定与筛选，第三部分 描述：待定。
Name:Targets, Assays & Screening, part 1
Description:Welcome, by the end of the course students will be able to: Recognize the differences between target-based and phenotypic drug discovery. Differentiate between common library types and screening approaches for identifying small molecule hits. Describe some of the assay types used in early screening and factors to consider in their design.
Name:Targets, Assays & Screening, part 2
Description:
Name:Targets, Assays & Screening, part 3
Description:
This course focuses on the early stages of drug discovery and the identification of promising compounds with which to begin the hunt for a novel drug. Different types of assays and methods are reviewed that are used to screen libraries of molecules in the preliminary search for compounds with activity. Methods are discussed for validating that active molecules are indeed engaging a target associated with a predicted therapeutic benefit. Target audience: This course is suitable for life scien
