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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/sleep
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课程名称：睡眠：神经生物学、医学与社会 课程概述：本课程的目标是为学生提供有关睡眠的生物学、个人及社会相关性的最新信息。个人相关性强调，前一晚睡眠质量是白天表现的最佳预测因素。大脑会主动产生睡眠，课程的第一部分概述了睡眠控制的神经生物学基础。课程提供了细胞层面上对睡眠剥夺、时差反应以及酒精、咖啡因和尼古丁等物质如何改变睡眠与清醒状态的理解。课程的第二部分涵盖了睡眠依赖的生理变化及睡眠障碍医学，特别强调过度嗜睡、失眠及自主控制的睡眠依赖变化。慢性睡眠剥夺会损害免疫功能并可能促进肥胖，4:00至6:00之间的死亡率最高，课程的第二部分强调了睡眠对预防医学的重要性。最后一部分将考虑睡眠的社会相关性。在一个日益复杂和技术导向的社会中，个人的操作错误可能对公共健康和安全产生灾难性的负面影响。由于疲劳相关的表现下降，已知造成核电站故障、交通灾害和医疗错误等因素之一。 课程大纲： 1. 单元01 - 课程介绍与睡眠与清醒的神经生物学（第一部分） 2. 单元02 - 睡眠与清醒的神经生物学（第二部分，荣誉轨道） 3. 单元03 - 睡眠-清醒调节的数学建模（荣誉轨道） 4. 单元04 - 睡眠的分子生物学与遗传学（荣誉轨道） 5. 单元05 - 睡眠医学概述（标准轨道） 6. 单元06 - 睡眠障碍与呼吸对心血管健康的影响（标准轨道） 7. 单元07 - 睡眠与精神障碍（标准轨道） 8. 单元08 - 失眠的原因与后果（标准轨道） 9. 单元09 - 失眠的治疗方法（标准轨道） 10. 单元10 - 睡眠与麻醉（标准轨道） 11. 单元11 - 昼夜节律、睡眠与健康（标准轨道） 12. 单元12 - 白天嗜睡与睡眠需求（标准轨道） 此课程为希望深入了解睡眠科学及其在医学和社会中的重要性的人士提供了全面的视角和知识基础。
Name:Unit 01 - Neurobiology Section: Course Introduction & Neurobiology of Sleep and Wakefulness (Part One) - (Standard Track & Honors Track)
Description:This unit begins with a Course Overview video from Ralph Lydic, Ph.D., followed by the first portion of the Neurobiology of Sleep and Wakefulness lecture, delivered by Helen Baghdoyan, Ph.D. PLEASE NOTE: Only the Course Overview video, and the Getting Started and Syllabus readings are required for students who have chosen to engage in the Standard Track portion of the course content. Standard track students may also bypass all content in units 2, 3, and 4, and instead move directly to unit 5 after viewing the Course Overview video.
Name:Unit 02 - Neurobiology Section: Neurobiology of Sleep and Wakefulness (Part Two) - (Honors Track)
Description:Unit 2 continues the lecture from Helen Baghdoyan, Ph.D. on the Neurobiology of Sleep and Wakefulness. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
Name:Unit 03 - Neurobiology: Mathematical Modeling of Sleep-Wake Regulation - (Honors Track)
Description:Unit 3 continues the Neurobiology section of the content with a lecture from Victoria Booth, Ph.D. on the Mathematical Modeling of Sleep-Wake Regulation. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
Name:Unit 04 - Neurobiology: Molecular Biology and Genetics of Sleep - (Honors Track)
Description:Unit 4 closes out the Neurobiology section with a lecture from Chiara Cirelli, Ph.D. on Molecular Biology and the Genetics of Sleep. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
Name:Unit 05 - Medicine: Overview of Sleep Medicine - Ronald Chervin, M.D. - (Standard Track)
Description:Unit 5 marks the beginning of the Medicine section of the course. This unit features an overview of Sleep Medicine from Ronald Chervin, M.D.
Name:Unit 06 - Medicine: Disordered Sleep and Breathing Alters Cardiovascular Health - (Standard Track)
Description:Unit 6 continues the Medicine section of the course, featuring a lecture from Helena Schotland, M.D. exploring how Disordered Sleep and Breathing may alter Cardiovascular Health.
Name:Unit 07 - Medicine: Sleep and Psychiatric Disorders - (Standard Track)
Description:Unit 7 further continues the Medicine section of the course with a lecture on the relationship of Sleep and Psychiatric Disorders from Eric Nofzinger, M.D
Name:Unit 08 - Medicine: Insomnia: Causes and Consequences - (Standard Track)
Description:Unit 8 further continues the Medicine section of the course with a lecture from Christopher Drake, Ph.D. on the causes and consequences of Insomnia.
Name:Unit 09 - Medicine: Treatments for Insomnia - (Standard Track)
Description:Unit 9 further continues the Medicine section of the course with a lecture from J. Todd Arendt, Ph.D. on the range of available treatments for Insomnia.
Name:Unit 10 - Medicine: Sleep and Anesthesia - (Standard Track)
Description:Unit 10 brings the Medicine section of the course to a close with a lecture on Sleep and Anesthesia delivered by George Mashour, M.D.
Name:Unit 11 - Society: Circadian Rhythms, Sleep, and Health - (Standard Track)
Description:Unit 11 kicks off the Society section of the course with a lecture on Circadian Rhythms, Sleep, and Health from Theresa Lee, Ph.D.
Name:Unit 12 - Society: Daytime Sleepiness and Sleep Need - Thomas Roth, Ph.D. (Standard Track)
Description:Unit 12 wraps up the final section of the course and the Society section of the content with a lecture on Daytime Sleepiness and Sleep Need by Thomas Roth, Ph.D.
The objective of this course is to give students the most up-to-date information on the biological, personal, and societal relevance of sleep. Personal relevance is emphasized by the fact that the single best predictor of daytime performance is the quality of the previous night's sleep. The brain actively generates sleep, and the first section of the course is an overview of the neurobiological basis of sleep control. The course provides cellular-level understanding of how sleep deprivation, jet lag, and substances such as alcohol, ,caffeine, and nicotine alter sleep and wakefulness. The second section of the course covers sleep-dependent changes in physiology and sleep disorders medicine. Particular emphasis will be placed on disorders of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic control. Chronic sleep deprivation impairs immune function and may promote obesity. Deaths due to all causes are most frequent between 4:00 and 6:00 a.m., and this second section of the class highlights the relevance of sleep for preventive medicine. The societal relevance of sleep will be considered in the final section of the class. In an increasingly complex and technologically oriented society, operator-error by one individual can have a disastrous negative impact on public health and safety. Fatigue-related performance decrements are known to have contributed as causal factors to nuclear power plant failures, transportation disasters, and medical errors.
