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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/pharmacokinetics
课程评论：没有评论
课程名称：药物动力学 课程概述：本课程以给药途径的回顾开始，深入探讨ADME（吸收、分布、代谢与排泄）以及利用体内药物浓度-时间数据来确定关键药物动力学参数，如分布容积、半衰期和清除率。课程强调了体外实验方法，这些方法能够快速预测ADME和PK特性，以便对新化合物进行评估。课程后期重点关注药物发现团队如何研究药物动力学/药效学（PK/PD）关系。 课程大纲： - **药物动力学第一部分**：欢迎您参加本课程，完成后学生将能够总结药物动力学（PK）、ADME（吸收、分布、代谢和排泄）、分布容积、半衰期和清除率的关键概念；区分不同的给药途径及其对PK参数的影响；定义和描述运输蛋白、血浆蛋白结合（PPB）以及药物间相互作用（DDIs）对药物分子PK的影响；解释PK/PD关系的推导过程及其在定义预期人用剂量中的重要性。 - **药物动力学第二部分**：待更新描述。 - **药物动力学第三部分**：待更新描述。
Name:Pharmacokinetics, part 1
Description:Welcome, by the end of the course students will be able to: Summarize the key concepts of pharmacokinetics (PK), ADME (Absorption, Distribution, Metabolism, and Excretion), volume of distribution, half-life and clearance. Differentiate between different routes of drug administration and their impact on PK parameters. Define and describe the influence of transporters, plasma protein binding (PPB) and drug-drug interactions (DDIs) on the PK of a drug molecule. Explain how PK/PD relationships are derived and their importance for defining the anticipated human dose.
Name:Pharmacokinetics, part 2
Description:
Name:Pharmacokinetics, part 3
Description:
This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance. The course then emphasizes in vitro assays that allow rapid prediction of ADME and PK properties for evaluation of new compounds. The later stages of the course focus on how drug discovery teams study this PK/PD relationship, a
