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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/personalizedmed
课程评论：没有评论
课程名称：个性化医学案例研究 概述：本课程探讨生物医学的进步如何有潜力革新药物开发、药物治疗和疾病预防，了解当前进展以及未来展望。课程将介绍基因学和药物反应变异的机制，并通过一系列案例研究说明如何利用基因学来优化诊断和个性化治疗，包括稀有病和常见病。同时，将讨论在临床实践中实施大规模基因组测序的伦理和操作问题。 完成本课程后，学习者将理解： 1. 基因变异如何影响人类疾病易感性。 2. 如何根据遗传因素选择药物疗法。 3. 现代测序技术发现的绝大多数基因变异的功能后果尚不明确。 该课程主要面向经过五年以上培训的医生，其他医疗人员、医学/健康科学学生以及公众也可能对此感兴趣。 课程启动日期：2016年1月15日 课程大纲： 1. 单元1：个性化医学的介绍 - 简要回顾个性化医学相关的基因基础知识及临床数据分析的统计概念。 2. 单元2：研究遗传变异 - 介绍家庭和人群的遗传学，及现代技术用于研究遗传变异的方法。 3. 单元3：个性化医学案例研究，第一部分 - 讨论具体案例，包括家族性高胆固醇血症和高风险药物遗传学案例。 4. 单元4：个性化医学案例研究，第二部分 - 分析如何利用个性化医学指导特定疾病的治疗决策，包括囊性纤维化、马凡综合征和癌症的案例。 5. 单元5：医疗照护系统中的个性化医学 - 回顾个性化医学的现状和未来展望，重点探讨如何在医疗系统中有效实施个性化医学，尤其是在信息学方面。 最后反思活动： 随着患者未来可能携带完整基因组来就医，如何利用这些信息改善护理将是重要议题。课程中将详细探讨特定基因变异在个体疾病易感性和对特定药物反应中的作用。学习者需选择适合自己的版本参与反思活动。
Name:UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE
Description:The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants), as well as review statistical concepts and skills important to clinical data analysis (odds ratios, relative risk, P values, multiple testing, sensitivity, specificity, ROCs). In Module 2 we will explore drug actions and reactions as we look closely at the general mechanisms underlying variability in drug responses, drug metabolism and transport, and genetic variability in drug-handling molecules.
Name:UNIT 2: STUDYING GENETIC VARIATION
Description:Module 3 focuses on how we study genetic variation. We'll start by looking at families and populations. Topics that will be introduced include family history and inheritance patterns, ancestry, and linkage. Then in Module 4 we shift our focus to studying the contemporary techniques and technologies used to study genetic variation, including genome-wide association and sequencing.
Name:UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 1
Description:In Module 5 we will begin to discuss specific cases as these apply to personalized medicine. We will first look very closely at a case of familial hypercholesterolemia as we investigate how we use genomic medicine to move from a rare disease to a common medication, using genomics to find new drug targets, and a discussion of the side effects of statin therapy. In Module 6 we will look at a collection of "high risk pharmacogenetics"cases that illustrate adverse reactions due to drug metabolism and variable drug responses.
Name:UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 2
Description:Module 7 continues our focus on case studies with a look at some cases that illustrate how personalized medicine informs treatment decisions related to specific diseases/conditions. These include cystic fibrosis, Marfan syndrome, heart failure, neuropsychiatric diseases, and diabetes. Three cases/lessons focus specifically on how genomic medicine informs testing for and treatment of cancer.
Name:UNIT 5: PERSONALIZED MEDICINE IN A SYSTEM OF CARE
Description:Module 8 serves as a review and a continuing discussion of the cases presented in Modules 5-7, as we take a look at where we are now and what's on the horizon in personalized medicine. In Module 9 we will explore some critical considerations for implementing and operationalizing personalized medicine in a system of care, particularly in the area of informatics. We will discuss the role of the electronic medical record in a learning healthcare system, how electronic records support discovery, and using electronic records in the delivery of personalized medicine.
Name:FINAL REFLECTION ACTIVITY
Description:We are on the verge of having patients come to their physicians with their entire genome sequenced. How can we best use this information to improve care? This course looks closely at many specific genetic variants that have been identified as playing a role in a person’s susceptibility to disease and/or potential for adverse reaction to certain substances/drugs. In the peer review activity below, please reflect on how your learning in this course has impacted your understanding of personalized medicine. There are two versions of this activity – one for healthcare professionals (doctors, nurses, pharmacists, medical students, etc.), and one for non-healthcare professionals (patients, consumers, general interest, etc.) Please be sure to choose the appropriate version of the activity.
Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. The ethical and operational issues around how to implement large scale genomic sequencing in clinical practice will be addressed. After completing this course, learners will understand 1. The ways in which genetic variants can contribute to human disease susceptibility 2. How to choose among drug therapies based on genetic factors 3. That the functional consequences of the vast majority of genetic variants discovered by modern sequencing are unknown. This course is targeted primarily at physicians 5+ years out of training. Other healthcare providers, medical/health sciences students, and members of the public may also be interested. Course launches January 15, 2016. * The information presented in “Case Studies in Personalized Medicine” is offered for educational and informational purposes only, and should not be construed as personal medical advice. If you have questions or concerns about a medical matter, please consult your doctor or other professional healthcare provider.
