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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/non-alcoholic-fatty-liver-disease--the-essentials
课程评论：没有评论
课程名称：非酒精性脂肪肝疾病基础知识 课程概述：非酒精性脂肪肝疾病（NAFLD）是一个全球性问题，影响多达25%的人群。这种疾病不仅增加了肝脏疾病的风险，还与心血管疾病和肝癌相关。课程将涵盖NAFLD的基础知识，首先介绍人类肝脏的生理学，接着讲解流行病学、病理生理学、临床医学和遗传学。课程还将讨论如何通过血液检测、影像学诊断和组织学诊断来诊断NAFLD，并涉及并发症和治疗选项，包括NAFLD与糖尿病发展的关系。最后，专家们将探讨基于组学技术的数据驱动的新生物标志物的识别。 完成课程后，您将对NAFLD有广泛的认识，从病因和病理生理学到临床检查和治疗。 课程大纲： 1. **肝脏 - 生理与疾病**：通过多个生化过程维持整体体内平衡，介绍肝脏的生理功能及重要生化概念。 2. **病因**：探讨非酒精性脂肪肝疾病的成因，包括流行病学数据、营养因素及遗传因素的影响。 3. **病理生理学**：介绍多重打击假说以及NAFLD患者肝功能的影响。 4. **诊断**：讨论如何通过非侵入性测试诊断NAFLD，并探讨何时需要进行额外的组织学评估，及组学技术在生物标志物识别中的应用。 5. **治疗**：探讨运动对肝脏健康的影响，提供锻炼指南，并介绍非酒精性脂肪肝疾病的药物治疗进展。 6. **并发症与前景**：讨论NAFLD与2型糖尿病之间的关系，强调筛查的重要性，并讨论由于NAFLD发展而导致的肝硬化患者的管理。 本课程将为参与者提供关于非酒精性脂肪肝疾病的全面知识和临床应用技能。
Name:The Liver - Physiology and Disease
Description:The liver contributes to overall body homeostasis through several biochemical processes and without these functions we cannot maintain life. In the first lectures, Professor Jens Juul Holst will discuss the physiology of the human liver focusing on biochemical concepts as gluconeogenesis, glycogenolysis, lipid and amino acid metabolism. The videos will also cover how external hormonal systems such as pancreatic islets regulate liver metabolism. After completing module 1 you will have a broad and basic understanding of the physiology and pathophysiology of the liver. In the subsequent modules, we will build on top of module 1 by exploring fatty liver disease.
Name:Causes
Description:What causes non-alcoholic fatty liver disease? This is the core question of module 2. We will kickstart this module by reviewing epidemiological data on non-alcoholic fatty liver disease by professor Peter Jepsen. In the second half, professor Bente Kiens will dig into which nutrients that may drive fat infiltration of the liver. The diversity in the risk of developing non-alcoholic fatty liver disease and NASH will be discussed from a genetic approach by doctor Stefan Stender.
Name:Pathophysiological aspects
Description:Professor Henning Grønbæk will commence module 3 with an overview of the multiple hit hypothesis followed by Hendrik Vilstrup who will describe how the liver function is affected in patients with NAFLD.
Name:Diagnostics
Description:Professors Flemming Bendtsen and Lise Lotte Gluud will discuss how to diagnose non-alcoholic fatty liver disease with or without fibrosis by non-invasive tests and describe when additional tests including histological assessment is required. Professor Mogens Vyberg will take us into the world of liver diagnostic by zooming in on the histological traits of liver tissue from patients with non-alcoholic fatty liver disease. The module will be concluded by perspectives on how ‘omics’ technologies such as protemics may contribute to identification of novel biomarkers in a lecture by Associate Professor Nicolai J. Wewer Albrechtsen and an interview with Professor Matthias Mann.
Name:Treatment
Description:Exercise is an important tool to improve the health of your liver. How exercise affect your liver will be introduced by Professor Bente Klarlund Pedersen and Associate Professor Nicolai J. Wewer Albrechtsen. Personal Trainer Samantha Mølgaard will give a practical guide on how to ‘exercise to improve your liver’. The evidence concerning the pharmacological treatment of non-alcoholic fatty liver disease is growing rapidly. Professor Guruprasad Aithal will introduce us to the current evidence and provide an insight into future drugs developed specifically for the treatment of non-alcoholic fatty liver disease.
Name:Complications and Perspective
Description:In the final module, Professor Henning Grønbæk will discuss the close relation between non-alcoholic fatty liver disease and type 2 diabetes. Furthermore, why it is important to screen individuals with type 2 diabetes for non-alcoholic fatty liver disease. Professor Jonel Trebicka will discuss the management of patients who have developed cirrhosis due to non-alcoholic fatty liver disease. Finally, Professor Lise lotte Gluud and Associate Professor Nicolai J. Wewer Albrechtsen will revisit some general aspects of non-alcoholic fatty liver disease and discuss its future aspects.
Non-Alcoholic Fatty Liver Disease (NAFLD) is a global problem, affecting up to 25% of all individuals. The disease not only increases the risk of liver disease, but also of cardiovascular disease and liver cancer. During this course, you will learn the essentials of NAFLD. We will begin with an introduction to the physiology of the human liver followed by epidemiology, pathophysiology, clinical medicine, and genetics. Diagnosing NAFLD based on blood tests, diagnostic imaging and histology will be discussed. Complications and treatment options will also be covered in this course including the link between NAFLD and the development of diabetes. Finally, experts will discuss data driven identification of new biomarkers by omics technologies. After completing this course, you will have a broad knowledge about NAFLD ranging from the aetiology and pathophysiology to bedside examinations and treatments.
