|
所在平台: Coursera |
课程主页: https://www.coursera.org/learn/intro-translational-science
课程评论：没有评论
课程名称：翻译科学导论 课程概述： 翻译科学旨在加速将研究发现从实验室转化为医疗实践的过程。然而，许多科学和组织障碍可能会妨碍这一转化进程，最终减缓医学研究的进展。美国国立卫生研究院（NIH）下属的国家翻译科学促进中心（NCATS）成立的目的是转变和加速翻译研究的过程，从而更快地为更多患者提供治疗。翻译科学领域力求通过以下方式弥补这些差距： 1. 开发新的方法、技术、资源和模型 2. 证明新方法、技术、资源和模型的有效性 3. 向广泛的科学社区传播相关的数据、分析和方法论 《翻译科学导论》是一门介绍性课程，旨在帮助学生全面理解翻译科学、其下进行的各种研究类型，以及这些研究如何影响公众。课程将对临床研究中当前的障碍与翻译科学的潜力进行比较，并包括来自罗切斯特大学的精选案例研究。 课程大纲： 1. 翻译科学的全貌与T1 - 向人类的转化 - 本节课提供临床和翻译科学以及CTSA计划的基本定义和核心概念的概述。学生将学习翻译研究的不同阶段及其进展中的障碍。 2. T2 - 向患者的转化与T3 - 向实践的转化 - 第三节课介绍T2研究，即将T1研究（人类）的发现转化为患者的研究。T2研究通常通过III期临床试验、观察性研究、证据综合和临床指南开发进行。第四节课介绍T3研究，将T2研究的发现转化为实际临床实践。 3. T4 - 向社区的转化与参与临床与翻译研究 - 第五节课介绍T4研究，即将T3研究的发现转化为社区（包括国内及全球）。T4研究通常通过预防与结果研究、大规模筛查研究和健康政策研究进行。第六节课概述如何参与临床与翻译研究，包括作为独立研究者、临床研究专业人员与研究志愿者的角色。最后一部分展示如果选中参与临床试验，典型的研究志愿者将经历什么。 通过本课程，学生将了解翻译科学的基本知识，掌握如何将理论应用于临床实践，从而促进医学及其相关领域的发展。
Name:Translational Science - The Big Picture and T1 - Translation to Humans
Description:The first lesson in Introduction to Translational Science provides an overview of the basic definitions and key concepts related to clinical and translational science and the CTSA program. Students will learn about the different stages of translational research and the roadblocks that impede progress across the spectrum.The second lesson in Introduction to Translational Science provides an introduction to T1 research which is research that translates findings from basic (laboratory) research to humans through developing treatments and interventions. T1 research is often conducted through observational studies, case studies, proof-of-concept studies, phase I clinical trials, and phase II clinical trials
Name:T2 - Translation to Patients and T3 - Translation to Practice
Description:The third lesson in Introduction to Translational Science provides an introduction to T2 research, which is research that translates findings from T1 research (humans) to patients. T2 research is often conducted through Phase III clinical trials, observational studies, evidence synthesis, and clinical guidelines development. The fourth lesson in Introduction to Translational Science provides an introduction to T3 research, which is research that translates findings from T2 research (patients) to actual clinical practices. T3 research is often conducted through Phase IV clinical trials, health services research, and clinical outcomes research.
Name:T4 - Translation to Communities and Participating in Clinical and Translational Research
Description:The fifth lesson of Introduction to Translational Science provides an introduction to T4 research, which is research that translates findings from practices (T3 research) to communities, both domestic and globally. T4 research is often conducted through prevention and outcome studies, mass screening studies, and health policy studies.The sixth lesson of Introduction to Translational Science provides an overview of how interested individuals can participate in clinical and translational research; as an independent research, as a clinical research professional, and as a study volunteer. The final segment of the module demonstrates what a typical study volunteer will encounter if they are selected to participate in a clinical trial.
Translational science seeks to speed up the process of moving research discoveries from the laboratory into healthcare practices. Numerous scientific and organizational roadblocks can act as obstacles along the path of translation and ultimately hinder the speed of progress in medical research. The National Center for Advancing Translational Sciences (NCATS) was established by the National Institutes of Health (NIH) to transform and accelerate the translational research process, with the intended result of getting treatments to more patients faster. The field of Translational Science aims to bridge these gaps by: Developing new approaches, technologies, resources and models Demonstrating the usefulness of new approaches, technologies, resources and models Disseminating the resulting data, analyses, and methodologies to the broad scientific community Introduction to Translational Science is an introductory course that provides students with a broad understanding of translational science, the types of research that are conducted under the translational science umbrella, and how this research impacts the public at large.The course will compare and contrast current impediments to clinical research with the potential of translational science and will include selected case studies from the University of Rochester.
