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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/industrial-biotech
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课程名称：工业生物技术 课程概述：自工业革命以来，化石燃料一直是社会的主要能源来源，为我们日常生活中许多看似理所当然的产品（如药品、食品及饮料、材料、塑料及个人护理用品）提供原材料。随着21世纪的推进，我们需要更智能、更可预测和更可持续的化学品制造解决方案。工业生物技术正在改变我们制造化学品和材料的方式，同时也为我们提供可再生能源的来源。它是可持续制造过程的核心，是传统制造技术的有吸引力的替代方案，以商业化推动和转变优先工业部门，为我们的环境提供越来越多可行的解决方案，包括新化学品、新材料和生物能源。 本课程将涵盖支撑生物技术研究的关键技术，包括酶的发现与工程、系统生物学和合成生物学、以及生化与工艺工程。课程内容将通过讲座的形式传达，以确保学生在这些关键领域拥有扎实的基础。此外，我们还将探讨可持续制造过程中涉及的更广泛问题，包括负责任的研究创新和生物伦理。 在课程的第二部分，我们将研究这些技术如何转化为惠及社会并影响我们日常生活的实际应用。这包括来自制药、化学和生物燃料行业的行业利益相关者和合作者的观点。 通过本课程的学习，学生将能够： 1. 理解酶的功能与催化。 2. 说明支撑系统生物学和合成生物学的技术和方法论。 3. 解释合成生物学应用的多样性，并讨论该研究中的不同伦理和监管/治理挑战。 4. 理解生物处理和生化工程在工业生物技术中的原则和作用。 5. 对支撑工业生物技术研究的关键技术进行有根据的讨论。 6. 举例说明工业生物技术产品和工艺及其在医疗、农业、精细化学品、能源和环境中的应用。 课程大纲包括： - **酶、酶的发现与工程**：探讨酶催化在生命中的中心地位和其在生物科学解决方案中的应用。 - **系统与合成生物学的方法**：讨论基因组序列的大规模读取与写入，合成生物学如何将生物学转化为工程学科。 - **生化与生物处理工程**：关注利用生物转化制造生物基化学品、生物制药和生物燃料的工艺设计。 - **药品与精细化学品**：研究使用生物催化法生产药品和精细化学品的工艺。 - **案例研究：生物能源与生物材料**：考察生物能源的产生及生物材料科学在工业和医疗产品中的应用。 - **案例研究：糖科学与生物治疗药物**：介绍糖科学的基本概念及其在制药和个性化医学中的应用。 本课程为工业生物技术的实际应用提供了详尽的知识基础，促进学生全面理解该领域的前沿科技与发展方向。
Name:Enzymes, Enzyme Discovery and Engineering
Description:Enzyme catalysts are central to life. They are the vehicles for delivering innovative bioscience solutions to chemicals manufacture, drug discovery, therapeutics and bioprocessing. They are the key enablers in the white biotechnology revolution, providing essential components in the new science of 'synthetic biology', offering new routes to biofuels, bulk and commodity chemicals and novel therapeutics.
Name:Methods in Systems and Synthetic Biology
Description:Recent advances in our ability to read and write genome sequences on a large scale have led to an ambitious vision for a new generation of biotechnology, often referred to as Synthetic Biology. Synthetic Biology aims at turning biology into an engineering discipline, in which organism engineers use computational tools to design biological systems with novel valuable functionalities, which are then built using advanced high-throughput genetic engineering, and tested by rapid screening technologies that collect diagnostic molecular profiles to drive improved designs in an iterative design-build-test cycle. This module will introduce the engineering concepts that inform Synthetic Biology and the cutting-edge technologies that underlie our dramatically increasing ability to construct living systems with custom-made functionalities. All stages of the design-build-test cycle for novel biosystems will be discussed, with a special focus on their integration in a unified bioengineering platform. Examples will focus on the application of Synthetic Biology as an enabling technology for the bioindustry, especially for the improved microbial production of high-value chemicals and drugs. A section on responsible research and innovation will explore the transformative potential of this innovative technology within a broader socio-economic context, creating awareness of the ethical and political implications of research in this field.
Name:Biochemical and Bioprocess Engineering
Description:Biochemical and bioprocess engineering is concerned with the design of processes which involve biological transformations to manufacture a range of bio-based chemicals, biopharmaceuticals and biofuels. Through applying knowledge of process constraints, which are usually described mathematically, biochemical engineers are able to design a series of integrated process steps or “unit operations” which together make up a bioprocess. This module will give an appreciation of the key role biochemical engineering has in translating discoveries coming from life sciences and synthetic biology, such as improved microbial platforms for product expression, into economically viable full scale production processes. Key engineering concepts and the problem solving approach required for the design of bioprocesses will be taught by a group of biochemical engineers from The University of Manchester, University College London and Technical University of Denmark.
Name:Pharmaceuticals and Fine Chemicals
Description:This module looks at the production of pharmaceuticals and fine chemicals using biocatalysis. Specifically, we will look at isolated biocatalytic transformations using isolated enzymes or whole cells as catalysts to manufacture commercially important products including pharmaceuticals, industrial monomers and personal care products. This module will be delivered by Dr Andy Wells of CHEM21, Europe’s largest public-private partnership dedicated to the development of manufacturing sustainable pharmaceuticals led by The University of Manchester and the pharmaceutical company GlaxoSmithKline. Dr Wells, alongside Dr Tom Dugmore of The University of York, will look at six industrial examples of biocatalytic reactions involving six different enzyme transformations. Each example will look at the product, manufacturing route, mechanism of the enzyme reaction and some of the sustainability drivers and metrics for adopting IB as part of the manufacturing route. Over the six examples, a number of key attributes of enzyme catalysed processes that need to be considered for successful scale-up will be examined. These include choice of free enzyme or whole cell catalyst, co-factors and co-factor recycling, multi-phase reactions, enzyme stability and throughput. Each example will have a number of references to the primary literature covering the product and enzyme type for further learning outside of the module.
Name:Case Studies: Bioenergy and Biomaterials
Description:Bioenergy is renewable energy extracted from biomass (organic biological material such as plants and animals, wood, waste, (hydrogen) gas, and alcohol fuels. Biomass is the fuel, bioenergy is the energy contained within that fuel. In this module we will look at biofuel production and the research and knowledge challenges associated with increasing the contribution of UK bioenergy to meet strategic environmental targets in a coherent, sustainable and cost-effective manner. In addition, we will be looking at biomaterials science and, in particular, the development of novel biomaterials and their application in a variety of industrial and medical products. Biomaterials can be derived either from nature or synthesized in the laboratory using a variety of chemical approaches utilizing metallic components, polymers, ceramics or composite materials. As a science it is around 50 years old so we will be considering the current trends and the future of biomaterials research and biomanufacturing technologies.
Name:Case Studies: Glycoscience and Biotherapeutics
Description:Glycoscience is the science and technology of carbohydrates, which are the most abundant biological molecules on Earth and make up part of the biology of all living organisms. This module will introduce the fundamental concepts of glycoscience, leading onto the benefits for society and how this drives and impacts the bioeconomy. A series of case studies will be used to present some of the key challenges and glycan-based solutions in pharmaceuticals and personalised medicine, food security and biomaterials. Biopharmaceuticals are new medicines that are made biologically. “Biologically” means that the production is too complex for simple chemistry and that we currently have to direct biological materials – cells, using the spectrum of natural catalytic reactions - to make these revolutionary medicines. We will be looking at the revolution in these development medicines within a clinical, societal and economic context and the approaches used to ensure production of safe and effective biopharmaceuticals, using various types of expression systems. Students will be introduced to detailed case studies that illustrate how the principles developed in other sub-modules are put into practice in the industrial context.
Fossil fuels have been the primary energy source for society since the Industrial Revolution. They provide the raw material for the manufacture of many everyday products that we take for granted, including pharmaceuticals, food and drink, materials, plastics and personal care. As the 21st century progresses we need solutions for the manufacture of chemicals that are smarter, more predictable and more sustainable. Industrial biotechnology is changing how we manufacture chemicals and materials, as well as providing us with a source of renewable energy. It is at the core of sustainable manufacturing processes and an attractive alternative to traditional manufacturing technologies to commercially advance and transform priority industrial sectors yielding more and more viable solutions for our environment in the form of new chemicals, new materials and bioenergy. This course will cover the key enabling technologies that underpin biotechnology research including enzyme discovery and engineering, systems and synthetic biology and biochemical and process engineering. Much of this material will be delivered through lectures to ensure that you have a solid foundation in these key areas. We will also consider the wider issues involved in sustainable manufacturing including responsible research innovation and bioethics. In the second part of the course we will look at how these technologies translate into real world applications which benefit society and impact our everyday lives. This will include input from our industry stakeholders and collaborators working in the pharmaceutical, chemicals and biofuels industries. By the end of this course you will be able to: 1. Understand enzymatic function and catalysis. 2. Explain the technologies and methodologies underpinning systems and synthetic biology. 3. Explain the diversity of synthetic biology application and discuss the different ethical and regulatory/governance challenges involved in this research. 4. Understand the principles and role of bioprocessing and biochemical engineering in industrial biotechnology. 5. Have an informed discussion of the key enabling technologies underpinning research in industrial biotechnology 6. Give examples of industrial biotechnology products and processes and their application in healthcare, agriculture, fine chemicals, energy and the environment.
