|
所在平台: Coursera |
课程主页: https://www.coursera.org/learn/industrial-bioprocess-development
课程评论：没有评论
课程名称：工业生物过程开发导论 课程概述： 本课程介绍了生物过程的基本概念，生物过程利用微生物、动物细胞或酶来制造新产品或完成化学转化。从古代以来，人类就开始利用微生物来转化生物材料，生产酒精饮料和其他发酵食品。随着时间的推移，生物过程已被开发用于各种商业产品的生产，从相对廉价的有机溶剂和工业酒精到昂贵的特种化学品。 课程大纲： 1. 模块1 - 微生物生物反应设计基础 本模块介绍微生物的一些特性，阐述其在工业生物过程发展中的重要性。学习如何在发酵过程中将糖转化为乙醇，以及19世纪和20世纪的重要发现，这些发现促进了抗生素和化学品的大规模生物生产。最后讨论重组蛋白、代谢工程及生物乙醇的商业生产。 2. 模块2 - 质量平衡与动力学 本模块涵盖工业发酵过程的主要分类：批量、补料批量和连续操作。学习这三种操作模式的主要特征，以及各类型生物反应器操作的优缺点。 3. 模块3 - 上游处理 学习发酵培养基中各个组分的来源和作用，设计良好的培养基对工业生物过程的成功至关重要。本模块还介绍常见的生物制造过程中采用的灭菌方法和微生物文化的保存技术，最后描述用于生产阶段接种物准备的一些要求。 4. 模块4 - 生物反应器工程 了解工业生物制造过程中常用的各种生物反应器类型。本模块还涵盖影响搅拌式反应器（STR）中生物过程发展的主要过程参数，并探讨将生物过程放大的常见策略，以最有效和经济的方式达到生产规模。 5. 模块5 - 下游处理 本模块将介绍生物产品下游处理的主要阶段，包括对常用的初步分离操作的回顾，并呈现详细的案例研究，展示获得细胞外（乳酸）和细胞内（酶）产品所需的复杂性。
Name:Module 1 - Fundamentals of Microbial Bioreaction Design
Description:In Module 1 you will find an introduction to some properties of microorganisms. Microorganisms are essential for the development of industrial bioprocesses. You will learn how they are used in fermentation processes for conversion of sugars into ethanol, e.g., for beer or vinegar production. Major discoveries during the 19th and 20th centuries that led to the bioproduction of antibiotics and chemicals on an industrial scale are also covered in this Module. A discussion on the use of recombinant proteins, metabolic engineering and commercial production of bioethanol is presented in the last part of the Module.
Name:Module 2 - Mass Balances and Kinetics
Description:Industrial fermentation processes are largely classified as batch, fed-batch or continuous operations. In Module 2 you will learn the main characteristics of these three operation modes. This Module also covers the advantages and disadvantages of each type of bioreactor operation.
Name:Module 3 - Upstream Processing
Description:In Module 3, you will learn about the different sources and roles of individual components of fermentation media. A well-designed fermentation medium is critical to the ultimate success of industrial bioprocesses at industrial scale. Students will be also introduced to the most common sterilization methods used in biomanufacturing processes at lab and industrial scale. In addition, we will be looking at different preservation techniques of microbial cultures. The Module will end up describing some requirements needed for the preparation of an inoculum to be used in the production stage.
Name:Module 4 - Bioreactor Engineering
Description:In this Module we will look at the different types of bioreactors that are commonly used for biomanufacturing processes at industrial scale. Module 4 also covers the main processes parameters that affect the development of a bioprocess in Stirred Tank Reactors (STRs). We will also explore the most common strategies to scale up a bioprocess in order to reach the production-scale level in the most efficient and economical manner.
Name:Module 5 - Downstream Processing
Description:Module 5 will cover the main stages of downstream processing of bioproducts. Along with the review of common operations used for primary isolation, this Module will present detailed case studies showcasing the complexity required to obtain both extracellular (lactic acid) and intracellular (enzymes) products.
Bioprocesses make use of microorganisms, animal cells, or enzymes to manufacture new products or complete a chemical transformation. Since ancient days, humans have been using microorganisms to transform biological materials for the production of alcoholic beverages and other fermented foods. Since then, bioprocesses have been developed for an enormous range of commercial products, from relatively cheap products such as organic solvents and industrial alcohol, to expensive specialty chemicals su
