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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/immunologyfundamentalsimmunitybcells
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课程名称：免疫学基础：先天免疫与B细胞功能 课程概述：本课程为免疫学基础三门课程的第一部分，旨在构建学生与医学界互动所需的词汇和概念，并以生动的方式增强记忆。课程通过生动的比喻、卡通和模型，介绍适应性免疫和先天免疫系统的基本功能。课后将详细讲解抗体的形式、功能、起源及其多样性，并通过基因重排、类别转换和亲和力成熟等机制进行深入探讨。 学习目标： - 理解适应性免疫与先天免疫系统的不同，及其保护人体免受各种病原体的特性； - 熟悉抗体及相关免疫球蛋白受体的详细结构，不同抗体类别的特征及其功能； - 掌握B细胞中DNA编码和表达这些结构的机制。 课程大纲： 1. 引入比喻 2. 调查免疫系统的细胞和器官 3. 先天免疫 4. 抗原与抗体 5. 免疫球蛋白基因 6. B细胞的发展 7. 结课 整个课程采用选择题进行测试，涵盖事实、概念和原则的应用，题目可能涉及课程中的图表、素描和照片。
Name:Introducing the Metaphors
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Name:Surveying the Cells and Organs of the Immune System
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Name:Innate Immunity
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Name:Antigens and Antibodies
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Name:Immuniglobulin Genes
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Name:Development of B Cells
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Name:Final
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Course 1 of a three course specialization called Fundamentals of Immunology. Each course in the specialization presents material that builds on the previous course's material. This is the first leg of a three-part journey through the defenses your body uses to keep you healthy. In this part we hope to give you the vocabulary and concepts you need to interact with the medical community and to provide them in a context that makes them memorable. Fundamentals of Immunology introduces students to the basic functions of the adaptive and innate immune systems. The early lectures survey cells, tissues and organs using metaphors, cartoons and models to improve understanding and retention. After describing the form, function, origin and varieties of antibodies, subsequent lectures provide details on the mechanism of the generation of variation. The course provides animations of gene rearrangement and class switching and descriptions of affinity maturation correlated with detailed physical models of antibody structure. The final lecture reviews these concepts in anatomical context. Testing employs multiple choice questions testing facts, concepts, and application of principles. Questions may refer to diagrams, drawing and photographs used in lecture and reproduced in the outline. What You’ll Learn: The difference between adaptive and innate immune systems, the characteristics of various pathogens that they protect you from and the overall strategies employed in this protection. The detailed structure of antibodies and related immunoglobulin receptors, the characteristics and function of the different antibody classes and the mechanism for producing both the recognition regions and stem regions. Finally, how these structures are coded for in the DNA and expressed in the B cells.
