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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/immunology-innate-immune-system
课程评论：没有评论
课程名称：免疫学：先天免疫系统 概述：我们的免疫系统依赖于先天免疫和适应性免疫两个部分相互沟通与协作，以便为我们提供最佳的对抗病原体的反应。本课程重点关注先天免疫，它为我们提供了针对感染的首要、快速和遗传防御。 在本课程中，您将深入了解在威胁暴露后的几分钟内发生的迅速反应中涉及的机制和细胞成分。通过我们活跃的研究人员的指导，学习将更加深入。 课程大纲： 1. 先天免疫系统的组成部分： 在第一模块中，我们将探索先天免疫系统的主要成分。我们将首先研究与潜在病原体首次接触的表面以及它们如何防止大多数病原体进入我们的身体。接着，我们将学习主要的先天保护机制，并讨论这一遗传系统如何识别和对抗感染。到本模块结束时，学习者将能够详细描述这些成分和机制。 2. 补体系统： 第二模块将探索我们先天免疫系统的一个关键可溶性成分：补体。我们将了解其主要成分、如何被病原体激活以及其结果如何导致病原体的破坏。我们还将探讨补体系统如何促进其他先天免疫活动，例如吞噬细胞对微生物的摄取和破坏。 3. 微生物组对先天免疫的编程： 第三模块将研究我们的微生物组如何在健康中发挥保护作用。我们将详细定义人类微生物组，并探索其对哮喘、糖尿病或癌症等多种常见病理的影响。模块结束时，学习者将有机会反思并与他人分享益生菌对健康的影响。 4. 抗原处理 - MHC I类和II类： 第四模块将帮助我们理解先天免疫系统如何与适应性免疫细胞进行沟通。我们将探索哪些细胞负责这一基本功能，以及它们如何捕获、消化和呈递病原体分子以激活适应性免疫细胞。重要的是，我们还将研究先天免疫反应如何帮助此响应的第二阶段“适应”于感染的性质。 5. 自然杀伤细胞： 第五模块将聚焦一种名为自然杀伤细胞的先天细胞示例，它们能够直接摧毁被感染和肿瘤化的细胞。我们将探讨它们如何与其他免疫细胞相互作用、如何识别目标细胞，并且它们用以促使目标细胞死亡的机制。重要的是，我们还将发现防止其误激活的机制，以避免损害健康宿主细胞的灾难性后果。
Name:Components of the innate immune system
Description:In module one, we will explore the main component of the innate immune system. We will start by looking at the surfaces that are first exposed to potential pathogens and how they prevent most pathogens from entering our body. We will then learn about our main innate protective mechanisms and discuss how this inherited system is able to recognise and combat infection. By the end of this module, learners will be able to describe these actors and mechanisms in detail.
Name:The complement system
Description:In module two, we will explore a key soluble component of our innate immune system: the complement. We will learn about its main components, how it gets activated by pathogens and how the outcome leads to pathogens destruction. We will also explore how the complement system contributes to other innate immune activities, such as phagocytosis, that is the uptake of microorganisms by immune cell for destruction.
Name:Programming of innate immunity by the microbiota
Description:In module three, we will investigate how our microbiota plays a protective role in our health. We will first define the human microbiome in more details and explore its influence on various common pathologies such as asthma, diabetes or cancer. The module ends on an opportunity for learners to reflect and share with others on the effects of pro-biotics on our health.
Name:Antigen processing - MHC Class I and Class II
Description:In module four, we will understand how the innate system communicates with the adaptive immune cells. We will explore which cells oversee this essential function and how they capture, digest and present pathogenic molecules to the adaptive immune cells to for their activation. Importantly, we will also investigate how the innate immune response helps this second phase of response to ‘adapt’ to the nature of the infection.
Name:Natural killer cells
Description:In module five, we will look at one example of innate cells, called Natural Killers, that are directly able to destroy infected and tumour cells. We will explore how they interact with other immune cells, how they recognise their target cells and the mechanisms they use to lead to their death. Importantly, we will also discover the mechanisms that prevent their mis-activation to prevent the disastrous destruction of health host cells.
Our immune system relies on an innate and an adaptive arm that communicate and collaborate to provide us with an optimal response against pathogens. This course focuses on our innate immunity which provides us our first, fast and inherited defence against infections. In this course, you will take a closer look at the mechanisms and cellular components involved in this swift response that occurs within minutes of exposure to a threat. Throughout the course, and guided by our active researchers,
