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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/immunology-immune-failures-and-cancer-immunology
课程评论：没有评论
课程名称：免疫学：免疫失败与癌症免疫学 课程概述：我们的免疫系统是一个强大的网络，能够保护我们免受外部威胁，如有害物质和病原体，以及能够导致疾病的细胞变化。当我们自然防御功能出现问题时，可能会导致免疫障碍。这些障碍可以表现为较轻微的问题，例如虫子过敏。更严重的情况则是自身攻击的免疫反应，可能导致局部或系统性组织损伤。 课程大纲： 1. **免疫缺陷** 在第一模块中，学员将探索我们免疫系统的基因调控。通过原发性免疫缺陷的例子，分析其对我们的先天和/或适应性反应的危害，讨论其个体的病理表现以及一些潜在的治疗研究方向。 2. **三级淋巴结构** 第二模块将带您了解三级淋巴结构。这些是由于慢性炎症而在组织中发展起来的免疫组织。您将探讨这些结构为何有时会妨碍或促进疾病的解决。 3. **肿瘤免疫学** 第三模块将揭示癌症的结果在很大程度上依赖于肿瘤与其微环境中免疫细胞之间的相互作用。您将从肿瘤逃逸机制的角度探讨这种关系，以及这些机制如何操控我们的免疫反应。最后，您将学习利用我们免疫系统对抗这种致命疾病的治疗方法。 4. **病毒持久性与人类癌症** 在本课程的最后一个模块中，您将探讨病毒持久性与癌症之间的关系。全球约百分之十的癌症负担可能与病毒相关，然而，病毒感染并不足以导致癌症的发展。您将研究我们免疫系统在这一复杂环境中的生理作用。
Name:Immunodeficiencies
Description:In module one, you will explore the genetic regulation of our immune system. Through the example of primary immuno deficiencies and looking at their detrimental effect on our innate and/or adaptive responses, you will discuss their individual pathological manifestation and some potential therapeutic avenues of investigation.
Name:Tertiary lymphoid structures
Description:In module two, our expert will take you on a journey to explore tertiary lymphoid structures. These are immunological organisations that develop in tissues affected by chronic inflammation in response to various alienations. Interestingly, you will explore why these structures can sometime hinder or benefit disease resolution.
Name:Tumour immunology
Description:In module three, you will discover that the outcome of cancer heavily relies on the crosstalk and relationship between the tumour and immune cells found in its micro-environment. You will explore this relationship from the point of view of tumour escape mechanisms and how these manipulate our immune response. Finally, you will learn about therapies that use our immune system to combat this deadly disease.
Name:Viral persistence and human cancer
Description:With approximately ten percent of the global cancer burden potentially attributed to viruses, our last module of the course, module four, will explore the relationship between viral persistence on cancers. Importantly, as viral infection is not sufficient for cancer to develop, you will investigate the physiological contribution of our immune system in this complex landscape.
Our immune system is a powerful network. It protects us from external threats, such as harmful substances and pathogenic agents, as well as cellular changes which could lead to diseases. Complications emerge when our natural defences do not function properly, which can result in immune disorders. These can take the form of less severe issues such as insect allergy. Others are more harmful, such as auto aggressive immune reactions, that lead to localised or systemic tissue damage. In this cour
