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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/immunology-adaptive-immune-system
课程评论：没有评论
课程名称：免疫学：适应性免疫系统 课程概述：本课程将深入探讨适应性（获得性）免疫系统在对抗病原体时所发挥的免疫反应角色。我们的研究团队来自免疫与炎症系，将重点关注淋巴细胞亚群及其参与的机制，这些机制在初次接触微生物抗原后，几天到几周内引发微妙而延迟的免疫反应。 课程大纲： 1. B细胞效应功能与耐受性： 本模块将介绍B淋巴细胞及其在对抗病原体方面的贡献。学习者将探索B细胞的发展过程、如何承诺成为功能性效应细胞，以及其效应机制。同时，我们将研究免疫系统如何防止B细胞对健康细胞过度反应。 2. T细胞激活、T辅助亚型及受体： 本模块将向学习者介绍T淋巴细胞的发展和区分为两种主要亚型的过程，以及它们如何协同形成适应性免疫反应并直接摧毁感染细胞。我们还将讨论身体如何防止这些强大细胞对宿主健康细胞发动攻击的机制。 3. 细胞毒性杀伤： 本模块将探讨部分T淋巴细胞直接杀死感染和肿瘤细胞的能力。学习者将了解到激活这些细胞的机制，比较其他互补免疫机制的直接杀伤方式，并理解其激活如何受到严格控制，以避免健康细胞的破坏。 4. 调节性T细胞： 本模块将关注一种特殊类型的T淋巴细胞——调节性T细胞的发育和功能。我们将深入研究它们在调节整体免疫反应以避免对宿主产生严重不良影响方面的机制，并讨论它们在人类健康中的治疗应用。 5. 淋巴细胞的循环与归巢： 本模块将带领学习者深入了解免疫细胞如何到达感染部位的机制。我们将探讨免疫细胞从血液迁移到感染组织的过程，并强调这一能力受严格调控的重要性。 6. 年龄对免疫系统功能的影响： 本模块将探讨衰老对免疫系统的影响。学习者将识别什么是“炎症衰老”（inflammaging），其原因及其对免疫系统的后果，并考虑这对人类健康的治疗方法所意味着的内容。 通过本课程，学习者将系统掌握适应性免疫系统的关键概念和机制，为进一步研究和应用打下坚实基础。
Name:B cell effector functions and tolerance
Description:In module one, learners will discover who B lymphocytes are and how they contribute to our immune response against pathogens. Together, we will explore how they develop, commit to becoming functional effector cells and what their effector mechanisms are. We will also investigate how the immune system prevents them from over-reacting against health cells.
Name:T cell activation, T helper subsets and receptors
Description:In module two, learners will discover how T lymphocytes develop, differentiate into two main sub-types and how these contribute to the orchestration of the adaptive immune response and the direct destruction of infected cells. We will also discuss the mechanism that our body has put in place to prevent these very powerful cells from turning against the host’s healthy cells.
Name:Cytotoxic killing
Description:In module three, we will explore the ability of some T lymphocytes to directly kill infected and tumour cells. We will learn about the mechanisms that activate them, contrast this with other complementary immune mechanisms of direct killing, and understand how their activation is kept under tight control to avoid the destruction of healthy cells.
Name:Regulatory T cells
Description:In module four, we will explore the development and function of a particular type of T lymphocytes, regulatory T cells, whose main role is to regulate the overall immune response to avoid serious detrimental outcome for the host. We will look at their mechanisms of action in more details and discuss their therapeutic application for human health.
Name:Lymphocyte recirculation and homing
Description:In module five, learners will be taken on a travel journey into our body to understand how the correct immune cells get to the correct site of infection. This will involve understanding the mechanisms by which immune cells migrate from the blood stream to infected tissues and sites of activation. Importantly, together with our expert here at Imperial, we will also explore the importance for this ability to be tightly regulated.
Name:The effect of age on the function of the immune system
Description:In module six, we will explore the impact ageing has on the immune system. We will identify what inflammaging is, its causes and its consequences on the immune system. We will reflect on what this means in terms of therapeutical approaches for human health.
In this course, you will learn about the role of immune responses of the adaptive (acquired) immune system which provides specialised immunity against pathogens. Guided by our researchers in the Department of Immunity and Inflammation, we will take a closer look at the lymphocyte subsets and mechanisms involved in this delayed finely tuned response occurring days to weeks after the initial exposure to microbial antigens. We will also focus on the versatile cellular components which can dis
