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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/genomics-research
课程评论：没有评论
课程名称：基因组学：解码生命的普遍语言 课程概述：本课程将探索基因组的概念，基因组包含细胞发展、功能和自我复制所需的所有信息，以及构成个体、植物或动物所需的信息。基因组不仅包含生物的完整基因组，还包括调节基因使用时机和方式的微小遗传结构。课程讨论的主题包括再生能力、心理疾病的早期预测、作物的营养潜力及生命历史等。通过本课程，您将了解到科学家如何解读基因组语言，以开发可持续的食品和燃料来源、改善疾病的治疗和预防、保护环境。 主讲教授：罗宾逊教授。此外，课程每个模块还邀请了来自生物学、物理学、计算机科学及其他领域的多位客座讲师，他们在基因组技术方面具有共同的兴趣，尽管各自的研究目标不同。 课程大纲： 1. 课程导向：熟悉课程和学习环境，掌握必要的技术技能。 2. 基因组是什么，为什么重要：了解基因组的现实意义与日常生活的关联。 3. 最初的基因组是什么样的，如何运作：探讨基因组的结构及功能。 4. 如何利用基因组了解健康与疾病：研究基因突变如何影响健康，以及基因的信息流动。 5. 基因组如何影响新器官或新作物的成长：研究相同基因组下不同细胞的功能与发展。 6. 基因组如何帮助我们预测健康问题：探讨自然与环境如何通过基因组影响健康。 7. 生态系统中基因组的合作与冲突：探索生物及其基因组与环境的复杂互动。 这门课程将为您提供对基因组学的深入理解，帮助您在科学研究和实际应用中运用这些知识。
Name:Course Orientation
Description:You will become familiar with the course, your classmates, and our learning environment. The orientation will also help you obtain the technical skills required for the course.
Name:What Is a Genome and Why Do We Care?
Description:Genes, genomes, DNA: these words have slipped into our daily news cycles and our awareness, but what they actually mean often remains unclear. In these lessons, we aim to give you, not just the Biology 101 explanation of what a genome is, but a real-life perspective on why you already care about genomics – perhaps in ways you didn’t even realize. Are you interested in where your food comes from, what health conditions you are most likely to develop, what fish will share your aquarium most successfully? Genomes are a key to finding a better answer to these and other everyday questions.
Name:What Were the First Genomes Like and How Do They Work Now?
Description:You may have seen DNA visually represented in different ways: a twisted ladder, a tangle of string, an array of sloppy X shapes, a row of letters. But what is DNA actually doing, and how does it relate to genes and the genome? How are scientists able to move from studying the physical structure of the genome to understanding its functionality? This module will help you become more comfortable with these ideas.
Name:How Can We Use Genomes to Understand the Healthy Body and Fight Diseases?
Description:Often, we hear about genes only when something goes wrong – when mutations, mistakes made in the DNA sequence, cause a disease like cancer cystic fibrosis. But what happens inside our cells that leads from a mutation in DNA to the physical symptoms of a disease? Why do some mutations cause positive outcomes, or no change at all? To answer these questions, we take a closer look at how information flows from genes, to RNA, to proteins, to all the physical structures and processes that make up living things.
Name:What Can Genomes Tell Us About How to Grow New Organs or New Crops?
Description:If all the cells in all the tissues and organs of our bodies have the same genome, how is it that they can look so different? How does a hair cell, a white blood cell, or a brain cell know what to do or where to go? The answer can be found by looking beyond the structure of the genome, into the timing of its activities. Recognizing how the information stored in the genome can be used in flexible ways shows us how living things can develop and change over time.
Name:How Might Genomes Allow Us to Predict Health Problems Before They Occur?
Description:You may have heard of "nature vs. nurture" or the modern day response, "nature AND nurture!" But how does "nurture," the environment, act through the genome? Can the biological effects of experience be passed from one generation to the next? And what does all of this have to do with everyday issues, like our physical and mental health? A closer look at two mechanisms that help regulate the activity for genes, epigenetic modifications and transcription factors, provides some answers.
Name:How Do the Genomes of Ecosystem Members Cooperate or Conflict?
Description:The world is a big and sometimes incomprehensibly complex place. Just as no gene in the genome acts in isolation, no living thing on this planet exists in isolation. In this final module of the course, we explore some of the rich, complicated interactions between living things, their genomes, and the world that surrounds them.
What is a genome? A genome contains all of the information that a cell needs to develop, function, and reproduce itself, and all the information needed for those cells to come together to form a person, plant, or animal. Genomes contain an organism’s complete set of genes, and also the even tinier genetic structures that help regulate when and how those genes are used. The ability to regrow a torn ligament, the clues that might predict the onset of mental illness, the nutritional potential of crops, and even the history of life itself, are all encoded in genomes. By taking this course, you will discover how scientists are deciphering the language of genomes to learn how to develop sustainable food and fuel supplies, improve disease treatment and prevention, and protect our environment. Professor Robinson is the main instructor for this course. In addition, each module features several guest instructors. These guest instructors come from diverse fields of study—biology, physics, computer science, and many others—and pursue diverse research goals, yet they share a common interest in genomic approaches and technologies. The guest instructors include: - Elizabeth (Lisa) Ainsworth, Associate Professor of Plant Biology - Mark Band, Director of the Functional Genomics Facility - Alison Bell, Associate Professor of Animal Biology - Jenny Drnevich, Functional Genomics Bioinformatics Specialist with High-Performance Biological Computing - Christopher Fields, Associate Director of High-Performance Biological Computing - Bruce Fouke, Director of the Roy J. Carver Biotechnology Center - Glenn Fried, Director of the Carl R. Woese Institute for Genomic Biology Core Facilities - Nigel Goldenfeld, Professor of Physics - Brendan Harley, Assistant Professor of Chemical and Biomolecular Engineering - Alvaro Hernandez, Director of the High-Throughput Sequencing and Genotyping Facility - Victor Jongeneel, former NCSA Director of Bioinformatics and former Director of High-Performance Biological Computing - Kingsley Boateng, Senior Research Specialist with the Carl R. Woese Institute for Genomic Biology Core Facilities - Stephen Long, Professor of Plant Biology and Crop Sciences - Ruby Mendenhall, Associate Professor of African American Studies - William Metcalf, Professor of Microbiology - Karen Sears, Assistant Professor of Animal Biology - Saurabh Sinha, Associate Professor of Computer Science - Lisa Stubbs, Professor of Cell and Developmental Biology - Rachel Whitaker, Associate Professor of Microbiology - Derek Wildman, Professor of Molecular and Integrative Physiology - Peter Yau, Director of the Protein Sciences Facility
