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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/extracellular-vesicles-health-disease
课程评论：没有评论
课程名称：细胞外囊泡在健康与疾病中的作用 课程概述：本课程旨在提供关于细胞外囊泡（EVs）及其在健康与疾病中的角色的最新理解。细胞外囊泡在细胞间通信中起着重要作用，除了维持正常的细胞生理外，EVs还传递可以推动或影响疾病进展的信息。本课程讨论了该领域的最新进展，介绍了EVs在健康和疾病中的功能。 课程包含四个模块： 模块1：课程介绍，概述了之前的MOOC课程“细胞外囊泡基础”。 模块2：专注于EVs在生理条件下的作用，举例说明它们在代谢、炎症、免疫、妊娠和凝血中的角色，同时简要讨论了微生物来源的EVs，如细菌囊泡，以及来自凋亡和衰老细胞的EVs。 模块3：重点探讨EVs在癌症中的作用，包括EVs如何介导肿瘤与肿瘤微环境之间的通信，免疫细胞来源的EVs在癌症发展中的功能角色，以及EVs在癌细胞增殖、生存、转移和耐药性中的作用。 模块4：介绍EVs在心血管、造血、神经、呼吸、泌尿系统疾病以及传染病中的作用。 本课程推荐给中级学习者或任何对此领域感兴趣的人，包括科学家、临床医生或细胞和分子生物学家，旨在拓宽他们对细胞外囊泡及其在特定疾病中作用的理解。
Name:Course Goals and Learning Objectives
Description:This course aims to provide current understanding about extracellular vesicles (EVs) and their role in health and diseases. The EVs are known to be involved in cell to cell communication. Apart from maintaining normal cell physiology, EVs deliver messages that can drive or influence the progression of a disease. This course discusses recent advances made in the field to give an introduction on their function in health as well as in disease. This course includes four modules. Module 1 is an introduction to the course, and provides an overview of the previous MOOC on EVs “Basics of Extracellular Vesicles”. Module 2 focuses on the role of EVs in physiological conditions and gives various examples on their role in metabolism, inflammation, immunity and pregnancy and coagulation. This module also briefly covers the topic of microorganism-derived EVs such as vesicles from bacteria and discusses EVs from apoptotic and senescent cells. In Module 3, we focus on the role of EVs in cancer: how EVs can mediate communication between the tumour and its microenvironment, the functional role of immune cell-derived EVs in development of cancer, as well as the role of EVs in cancer cell proliferation, survival, metastasis and drug resistance. In Module 4, the role of EVs in diseases of the cardiovascular, haematopoietic, nervous, respiratory and urinary systems, and infectious diseases will be presented. This course is recommended for intermediate learners or anyone who is interested in the field of extracellular vesicles and their role in a particular disease including scientists, clinicians, or cell and molecular biologists who look to broaden their understanding of the field.
Name:Physiological Function of EVs
Description:In this module, we will discuss the role of extracellular vesicles in maintaining cellular homeostasis, why they are important for this process. How microorganism such as in gram positive and negative bacteria can secrete EVs, will be discussed. Altered EV secretion as a response to inflammation, stress and apoptosis or senescence will be highlighted. Furthermore, some examples will be provided on how EV cargo can influence cellular metabolism and the function of EVs in maintaining physiology of cells in pregnancy and coagulation.
Name:Pathophysiology of EVs in Cancer
Description:This module will highlight the role of EVs in the progression of cancer and how the cargo delivered via EVs can directly influence cancer cell proliferation or metastatic properties. The communication between tumour and immune cells, stromal, and endothelial cells will be discussed. We will cover some of the considerations and guidelines that are important in utilising EVs as cancer biomarkers. Techniques that are commonly used to detect EVs, selection of biofluid for tumour EV biomarker analysis, model used in studying EVs, selection of specific EV cargo as biomarker and examples for studies on EVs as cancer biomarkers will be highlighted.
Name:Pathophysiology of EVs in Various Diseases
Description:We will discuss the reported role of EVs in mediating the development of various diseases such as cardiovascular diseases, hematological disorders, neurological diseases, urological, respiratory diseases and infectious diseases. This module will also highlight some of the proposed EV associated biomarkers and some therapeutic strategies by utilizing EVs to deliver inhibitory molecule.
This course aims to provide current understanding about extracellular vesicles (EVs) and their role in health and diseases. The EVs are known to be involved in cell to cell communication. Apart from maintaining normal cell physiology, EVs deliver messages that can drive or influence the progression of a disease. This course discusses recent advances made in the field to give an introduction on their function in health as well as in disease.This course includes four modules. Module 1 is an introduction to the course, and provides an overview of the previous MOOC on EVs “Basics of Extracellular Vesicles”. Module 2 focuses on the role of EVs in physiological conditions and gives various examples on their role in metabolism, inflammation, immunity and pregnancy and coagulation. This module also briefly covers the topic of microorganism-derived EVs such as vesicles from bacteria and discusses EVs from apoptotic and senescent cells. In Module 3, we focus on the role of EVs in cancer: how EVs can mediate communication between the tumour and its microenvironment, the functional role of immune cell-derived EVs in development of cancer, as well as the role of EVs in cancer cell proliferation, survival, metastasis and drug resistance. In Module 4, the role of EVs in diseases of the cardiovascular, haematopoietic, nervous, respiratory and urinary systems, and infectious diseases will be presented.This course is recommended for intermediate learners or anyone who is interested in the field of extracellular vesicles and their role in a particular disease including scientists, clinicians, or cell and molecular biologists who look to broaden their understanding of the field.
