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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/exposome
课程评论：没有评论
课程名称：《外显子组：破解我们生病的科学》 课程概述：本课程探讨疾病的成因，我们知道大多数疾病是基因与环境（自然与养育）的结合所致。单靠基因并不足以决定我们的命运。对于大多数复杂疾病，外部因素，即广义上的环境因素，更为重要，包括生活和工作环境、饮食、社会支持和压力、污染以及对感染源的接触。外显子组研究旨在发现健康和疾病的非遗传驱动因素。 外显子组一词源于“暴露”一词，表示我们在一生中所经历的所有暴露的总和，同时也代表因外部暴露而引发的生物反应。 在本课程中，来自乌得勒支大学和NWO Gravitation项目Exposome-NL的七位研究人员将分享他们的专业知识。课程将介绍外显子组的概念、其重要性、如何测量外显子组及建立与健康结果关联所需的数据科学步骤。课程最后将反思如何推动这一新兴且具有变革性的研究领域的发展。 外显子组研究需要跨学科的方法，因此本MOOC将吸引公共健康、环境健康、生命科学、临床医学、地球科学、人与社会科学及行为科学等领域的现有和未来学生及研究人员的兴趣。 课程大纲： 1. **外显子组概念简介**：提供课程的一般信息，包括学习目标、结构和完成要求。开篇由Roel Vermeulen教授进行导言，并安排同行讨论和小测验。 2. **外显子组方法的变革力量：以心血管疾病研究为例**：探讨外显子组方法如何改变心血管疾病病因研究。 3. **外部外显子组：方法论方法**：学习如何评估外部外显子组，重点关注空气污染和食品环境这两种暴露。 4. **内部外显子组：方法论方法**：深入了解内部外显子组，重点关注代谢组学这一重要方法。 5. **分析外显子组数据的数据科学步骤**：探索数据科学在外显子组研究中的角色及新颖的数据科学解决方案。 6. **未来展望与下一代研究**：课程最后，Roel Vermeulen教授描述近期可期待的外显子组成果，一些专家反思外显子组研究领域面临的挑战和未来展望。
Part: 1
Title:Introduction to the Exposome concept
Description:Welcome! Here you will find general information about the course. The learning objectives, the structure, and the requirements of completion will be presented to you. We will kick off with an introductory lecture by Prof. dr. Roel Vermeulen, a peer discussion assignment and a short quiz.
Part: 2
Title:The transformative power of Exposome approaches: using the example of cardiovascular disease reasearch
Description:This week we will learn about how Exposome approaches are changing research into the etiology of cardiovascular diseases.
Part: 3
Title:The external Exposome: methodological approaches
Description:This week we will address what the external Exposome is and how we can assess it. We will focus on two exposures: air pollution and the food environment.
Part: 4
Title:The internal Exposome: methodological approaches
Description:This week we delve into what the internal Exposome is, with a focus on metabolomics as one important approach.
Part: 5
Title:Data science steps for analysing Exposome data
Description:This week we look at the role of data science in Exposome research and the novel data science solutions.
Part: 6
Title:Future perspectives & the next generation of studies
Description:In this final week of the course Roel Vermeulen describes which exposome deliverables we can expect in the near future. Some of the experts reflect on challenges and future perspectives in the field of Exposome research.
What are the causes of disease? We know that most diseases result from a combination of genes and environment (nature and nurture). Our genes alone do not determine our fate. For most complex diseases, externalities - environmental factors in the broad sense - are more important. This includes our living and working environments, diet, social support and stress, pollution, and exposure to infectious agents. Exposome research is about discovering the non-genetic drivers of health and disease. Derived from the term exposure, the Exposome represents the totality of exposures we face throughout our lifetime. It also represents the biological responses that arise from external exposures. In this course, 7 researchers from Utrecht University and/or the NWO Gravitation programme Exposome-NL will offer their expertise. We will introduce you to the Exposome concept; why it’s important; how we measure the exposome; and the data sciences steps needed to establish associations with health outcomes. This course will conclude with reflections on what is needed to advance this nascent and transformative field of research. Exposome research requires transdisciplinary approaches. Therefore, this MOOC will be of interest to current and prospective students and researchers in the fields of public health, environmental health, life sciences, clinical medicine, geosciences, humanities, and social and behavioural sciences.
