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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/cancer-metastasis
课程评论：没有评论
课程名称：理解癌症转移 课程概述：每年，美国有超过50万人和全球超过800万人因癌症而死亡。随着人们寿命的延长，癌症的发病率在全球不断上升，预计到2030年，每年将有超过2000万人被癌症侵袭。每个人在一生中都或多或少会受到癌症的影响。得益于长期的研究和对疾病的承诺，我们在癌症的预防和治疗方面取得了巨大进展，但仍需做大量工作。 在本课程中，约翰霍普金斯医学院的医生和科学家将讲解癌症如何扩散或转移。我们将描述转移的主要理论及其生物学机制，以及转移所影响的主要器官，并探讨转移如何危害患者。 课程大纲： 1. **转移的历史与概述**：本模块将集中讨论转移的历史和概述，了解癌症的定义及我们如何开始理解转移的历程。 2. **原发肿瘤的生长与新生血管生成**：本模块将重点讨论癌症的一个特征——细胞的失控分裂，以及突变和新生血管生成在肿瘤形成中的角色，同时还将关注原发肿瘤微环境及其组分细胞类型。 3. **上皮-间质转化/侵袭/进入血管**：本模块将着眼于原发肿瘤形成后的步骤，包括癌细胞的上皮-间质转化、局部肿瘤侵袭和进入血液或淋巴管。 4. **循环中的存活与外侵**：我们将深入探讨癌症在循环系统中的存活、循环系统在转移中的作用、转移潜力的遗传决定因素、信号机制、趋化因子、停靠与锁定假说，以及外侵现象。 5. **休眠与继发肿瘤生长**：本模块将关注肿瘤休眠和继发肿瘤生长如何增加癌症的致死性。 6. **转移相关的发病率与死亡率**：在之前的模块中，我们详细研究了转移的各个步骤及其生物学机制。本模块将讨论转移所造成的发病和死亡，也就是说，癌症是如何伤害和致死患者的。 这门课程旨在加强人们对癌症转移机制的理解，为未来的癌症治疗和研究提供基础。
Name:History and Overview of Metastasis
Description:In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.
Name:Primary Tumor Growth and Neoangiogenesis
Description:In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.
Name:EMT / Invasion / Intravasation
Description:During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.
Name:Survival in the Circulation and Extravasation
Description:We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.
Name:Dormancy and Secondary Tumor Growth
Description:In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.
Name:Morbidity and Mortality Associated with Metastasis
Description:In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030. Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done. In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.
