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所在平台: Coursera |
课程主页: https://www.coursera.org/learn/basic-principles-of-cell-signaling
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课程名称：细胞信号传导基础原理 课程概述：多细胞生物体的生命协同通过细胞对各种内外部信号的精确控制进行调节。细胞依赖不同类型的信号来调节其生长、分裂、代谢和死亡。这些信号可以是其他细胞产生并分泌的生长因子或激素，也可以是来自环境的营养物质等分子。信号分子通过与特定受体分子的直接结合来被感知。根据分子的生化特性和变化方式，我们可以将不同的信号事件归纳为特定的信号传导通路。通过特定的信号转导通路，信号可以调节细胞活动和基因表达，从而引起细胞生长、代谢、分化或其他多种细胞功能的变化。当某些细胞信号通路中关键蛋白质发生基因突变或生化变化时，细胞的稳态可能会被打破，导致组织功能障碍、癌症的发生或扩散以及发育异常。因此，分析这些细胞信号通路的生化原理对于我们更好地理解正常细胞和病理状态的机制至关重要，从而为开发有效的治疗药物对抗疾病提供有价值的信息。 该课程为期6周，将为您提供细胞信号传导基础的坚实介绍。首先，我将定义细胞信号传导的概念，并介绍主要类型的细胞信号事件。在接下来的6周中，我们将学习电信号、化学信号和间隙连接介导的信号通路的生化基础。我们还将通过研究蛋白质-蛋白质相互作用及信号二级分子的意义，来学习信号转导通路的关键原理。在每周的最后，我们将介绍和讨论癌症、糖尿病等病理状态下的细胞信号失调。大家都知道，细胞信号传导对维持生命至关重要。您能用生化细节解释胰岛素如何降低葡萄糖吗？我们身体中氧感知的基本模式是什么？您是否想过如何选择性地消除或杀死某些快速生长的癌细胞？细胞信号传导伴随着多种生化策略来感知和传递细胞内部的信号。如果没有对这些信号过程的精细控制，细胞、组织和生物体将无法维持生命。 课程大纲： 第1模块：细胞信号传导及电信号介绍 第2模块：受体酪氨酸激酶信号传导 第3模块：受体丝氨酸/苏氨酸激酶信号传导 第4模块：G蛋白偶联受体信号传导 第5模块：其他细胞信号传导通路 第6模块：感知内外部环境 期末考试
Name:Module 1 : Introduction of Cell Signaling & Electrical Signaling
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Name:Module 2: Receptor tyrosine kinase signaling
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Name:Module 3: Receptor serine/threonine kinase signaling
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Name:Module 4: G protein coupled receptor signaling
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Name:Module 5: Other cell signaling pathways
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Name:Module 6: Sensing internal and external conditions
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Name:Final exam
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The coordination of life in multicellular organisms is precisely controlled by cells via various internal and external signals. Cells depend on different types of signals to regulate their growth, division, metabolism as well as death. Signals are growth factors or hormones produced and secreted by other cells. Some signals such as nutrients are in the form of molecules from the environment. Signaling molecules are sensed by direct binding to specific receptor molecules. Depending on the biochemical properties and ways of molecules changes, we can group various signaling events in defined pathways. Throughout specific signal transduction pathways, a signal can modulate cellular activities and gene expression, thereby leading to changes in cell growth, metabolism, differentiation, or many other cellular functions. When genetic mutations or biochemical changes occur in key proteins of certain cellular signaling pathways, cellular homeostasis can be disrupted, thus triggering tissue malfunctions, itiation or spread of cancer, or developmental anomalies. Dissecting biochemical principles of these cell signaling pathways is essential for us to better understand mechanisms of both normal cells and pathological conditions, therefore our knowledge on signal transduction will provide valuable information to develop effective therapeutic agents to fight against diseases.. This 6 week-course will give you a solid introduction to the basic fundamentals of cell signaling. I will first define the concept of cell signaling and introduces major types of cellular signaling events. Throughout 6 weeks, we will study biochemical basis of electrical signaling, chemical signaling as well as gap junction-mediated signaling pathways. We will also learn about key principles underlying signal transduction pathways by studying significance of protein-protein interactions and signaling second messengers. In the end of each week, dysregulated cell signaling in pathological conditions such as cancer and diabetes will be presented and discussed. Everyone knows that cell signaling is essential for sustaining life. How can you explain insulin actions in lowering glucose in biochemical details? What can be the fundamental mode of oxygen sensing in our body? Have you ever thought about ways of how we can specifically remove or kill certain types of rapidly-growing cancer cells? Cell signaling accompanies various biochemical strategies to sense and transmit signals inside our cells. Without fine control of those signaling processes, cells, tissues, and organisms cannot maintain life.
