开始时间: 04/22/2022 持续时间: Unknown
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所在平台: CourseraArchive 课程类别: 医学 大学或机构: University of Melbourne（墨尔本大学） 授课老师： Marnie Blewitt |
课程主页: https://www.coursera.org/course/epigenetics
课程评论：没有评论
Each mammalian cell has the same genes, yet performs distinct functions. This is achieved by epigenetic control of gene expression; the switching on and switching off of genes. This course will cover the principles of epigenetic control of gene expression, how epigenetic control contributes to cellular differentiation and development, and how it goes wrong in disease.
Introduction to epigenetics
Epigenetic modifications and their function in regulating gene expression and chromosome structure
DNA methylation, covalent histone modifications, histone variants, chromatin structure, noncoding RNAs and 3D organisation of the nucleus
Epigenetic phenomena in lower organisms
Position effect variegation, dosage compensation, paramutation
Mammalian epigenetics
Epigenetic reprogramming, genomic imprinting, X inactivation
Epigenetic deregulation in disease
Rett syndrome, ICF syndrome, Imprinting disorders, cancer
Epigenetics and the environment (diet, maternal environment, maternal care)
The Agouti viable yellow allele in mice, maternal care in rats, Dutch famine in humans
Each mammalian cell has the same genes, yet performs distinct functions. This is achieved by epigenetic control of gene expression; the switching on and switching off of genes. This course will cover the principles of epigenetic control of gene expression, how epigenetic control contributes to cellular differentiation and development, and how it goes wrong in disease.
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