Plant Bioinformatics Capstone

开始时间: 08/01/2020 持续时间: Unknown

所在平台: Coursera

课程类别: 其他类别

大学或机构: CourseraNew

   

课程主页: https://www.coursera.org/learn/plant-bioinformatics-capstone

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课程详情

The past 15 years have been exciting ones in plant biology. Hundreds of plant genomes have been sequenced, RNA-seq has enabled transcriptome-wide expression profiling, and a proliferation of "-seq"-based methods has permitted protein-protein and protein-DNA interactions to be determined cheaply and in a high-throughput manner. These data sets in turn allow us to generate hypotheses at the click of a mouse or tap of a finger. In Plant Bioinformatics on Coursera.org, we covered 33 plant-specific online tools from genome browsers to transcriptomic data mining to promoter/network analyses and others, and in this Plant Bioinformatics Capstone we'll use these tools to hypothesize a biological role for a gene of unknown function, summarized in a written lab report. This course is part of a Plant Bioinformatics Specialization on Coursera, which introduces core bioinformatic competencies and resources, such as NCBI's Genbank, Blast, multiple sequence alignments, phylogenetics in Bioinformatic Methods I, followed by protein-protein interactions, structural bioinformatics and RNA-seq analysis in Bioinformatic Methods II, in addition to the plant-specific concepts and tools introduced in Plant Bioinformatics and the Plant Bioinformatics Capstone. This course/capstone was developed with funding from the University of Toronto's Faculty of Arts and Science Open Course Initiative Fund (OCIF) and was implemented by Eddi Esteban, Will Heikoop and Nicholas Provart. Asher Pasha programmed a gene ID randomizer.

植物生物信息学的基石:过去15年是植物生物学令人兴奋的一年。已经对数百个植物基因组进行了测序,RNA-seq已实现了转录组范围内的表达谱分析,基于“ -seq”的方法的广泛使用已使蛋白质-蛋白质和蛋白质-DNA相互作用得以廉价且高通量地测定方式。这些数据集又使我们能够通过单击鼠标或轻按手指来生成假设。 在Coursera.org上的植物生物信息学中,我们涵盖了33种特定于植物的在线工具,从基因组浏览器到转录组数据挖掘到启动子/网络分析等,在本植物生物信息学的顶峰中,我们将使用这些工具来假设植物的生物学作用。功能未知的基因,总结在书面实验室报告中。 本课程是Coursera上植物生物信息学专长的一部分,介绍了核心生物信息学能力和资源,例如NCBI的Genbank,Blast,多重序列比对,生物信息学方法I的系统发育学,然后是蛋白质-蛋白质相互作用,结构生物信息学和RNA-seq除了在《植物生物信息学》和《植物生物信息学顶点》中介绍的特定于植物的概念和工具之外,还进行了生物信息学方法II中的分析。 这门课程/基石是由多伦多大学艺术与科学学院开放课程倡议基金(OCIF)资助开发的,并由Eddi Esteban,Will Heikoop和Nicholas Provart实施。 Asher Pasha对基因ID随机程序进行了编程。

课程大纲

Exploring your gene of interest with online databases
Identifying genes related to your gene of interest
Analysis of the function of your gene of interest and its network of genes
Lab report draft
Final copy of lab report

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