Cellular Garbage Disposal: Misfolded Proteins in Normal Biology and Human Disease

开始时间: 01/01/2014 持续时间: 未知

所在平台: MIT OCW

课程类别: 生物与生命科学

大学或机构: ocw


课程主页: http://ocw.mit.edu/courses/biology/7-346-cellular-garbage-disposal-misfolded-proteins-in-normal-biology-and-human-disease-fall-2011

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The endoplasmic reticulum (ER) orchestrates different cellular processes by which proteins are synthesized, correctly folded, modified and ultimately transported to their final destinations. As part of this crucial biosynthetic process, proteins that are not properly folded and consequently detrimental to normal cellular function are constantly generated. A common signature of many neurodegenerative diseases, including Alzheimer's and Parkinson's, is accumulation and deposition of misfolded proteins that arise when the ability of cells to deal with the burden of misfolded proteins is compromised. In this course, we will explore how the ER quality control machinery ensures that only properly assembled proteins exit the ER while distinguishing between nascent proteins en route to their biologically active folded state from those that are terminally misfolded.